Noishiki Y
J Thorac Cardiovasc Surg. 1978 Jun;75(6):894-901.
Neointimae of fabric vascular prostheses of three types (crimped and knitted [A], stretchable [B], and expansile [C]) were examined under both light and electron microscopes from 1 to 1,240 days after implantation in the thoracic aorta of 161 dogs. With all types of prostheses, a very uniform arrangement of smooth muscle cells was observed beneath the endothelial cells. In the crimped and knitted prostheses (A), the smooth muscle cells in the neointima showed a regular arrangement perpendicular to the direction of the bloodstream at each inner ridge of the crimp. In the stretchable prostheses (B), which can stretch only longitudinally, the long axes of the smooth muscle cells oriented in rows parallel to the bloodstream. In the expensive prostheses (C), which can expand only circumferentially, the smooth muscle cells were perpendicular to the bloodstream. These observations suggest that the arrangement of the smooth muscle cells in neointima is largely governed by the tension to which they are subjected.
在161只犬的胸主动脉植入三种类型（卷曲编织型[A]、可拉伸型[B]和可扩张型[C]）的人造血管织物后，于术后1天至1240天期间，分别在光学显微镜和电子显微镜下检查新生内膜。对于所有类型的假体，在内皮细胞下方均观察到平滑肌细胞排列非常均匀。在卷曲编织型假体（A）中，新生内膜中的平滑肌细胞在卷曲的每个内嵴处呈垂直于血流方向的规则排列。在仅能纵向拉伸的可拉伸型假体（B）中，平滑肌细胞的长轴成排平行于血流方向排列。在仅能周向扩张的可扩张型假体（C）中，平滑肌细胞垂直于血流方向。这些观察结果表明，新生内膜中平滑肌细胞的排列在很大程度上受其所承受张力的支配。
