Pediatric Rheumatology, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción.
Pediatrics, Pediatric Department, Central Hospital of the Social Welfare Institute, Asunción.
Reumatismo. 2022 Feb 7;73(4). doi: 10.4081/reumatismo.2021.1448.
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C) is a new acute-onset systemic inflammatory disease, which mainly affects children. Latent tuberculosis infection (LTBI) is characterized by the presence of immune sensitization to Mycobacterium tuberculosis (MTB) in the absence of any clinical or radiological evidence of active disease. We present a child with MIS-C related to COVID-19, with latent TB in the bone marrow, and satisfactory response to tocilizumab. It is important to pay attention in the investigation of TB cases in countries with a high prevalence of tuberculosis, especially when opting for immunusuppression.
儿童炎症性多系统综合征与 COVID-19 相关（PIMS-TS）或儿童多系统炎症综合征（MIS-C）是一种新的急性发作全身性炎症性疾病，主要影响儿童。潜伏性结核感染（LTBI）的特征是存在对结核分枝杆菌（MTB）的免疫致敏，而没有任何临床或放射学证据表明存在活动性疾病。我们报告了一例与 COVID-19 相关的 MIS-C 患儿，骨髓中有潜伏性 TB，对托珠单抗反应良好。在结核病高发国家，特别是在选择免疫抑制时，对 TB 病例进行调查非常重要。
