School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian Area, Tangshan, 063210, Hebei Province, People's Republic of China.
Department of Endocrinology, North China University of Science and Technology Affiliated Hospital, Tangshan, People's Republic of China.
BMC Med Genomics. 2022 Feb 8;15(1):22. doi: 10.1186/s12920-022-01177-0.
Previous studies on the relationship between ACE I/D, ACE2 G8790A and CYP11B2-344T/C gene polymorphisms and essential hypertension (EH) were inconsistent. Moreover, few studies have reported the combined effect of these gene polymorphisms and noise exposure on EH. The purpose of this study was to explore the combined and separate effects of ACE I/D, ACE2 G8790A and CYP11B2-344T/C gene polymorphisms and noise on EH among steelworkers.
A case-control study was conducted on 725 male workers between March 2014 and July 2014 in the Tangsteel Company, China. The noise exposure of the workers were measured. Logistic regression and crossover analysis were used to analyse the effects of the interactions on the EH among steelworkers. GMDR was used to determine the best combination model of gene-noise interactions.
Multivariate logistic regression showed that noise exposure increased the odds of EH, and the OR is 1.52 (95% CI 1.04-2.22). The risk of having EH for ACE I/D DD genotype carriers was 1.99 times that for II genotype carriers (95% CI 1.14-3.51). There was a negative additive interaction between ACE2 G8790A and CYP11B2-344T/C on EH (U3 = - 2.221, P = 0.026, and S = 0.128) and a positive multiplicative interaction between ACE I/D and CYP11B2-344T/C on essential hypertension (P = 0.041). In addition, there was no significant gene-noise interaction model through the GMDR method after adjusting the confounders.
The ACE DD genotype may make men susceptible to EH. Simultaneously carrying the DD genotype of ACE I/D and the TC genotype of CYP11B2-344T/C increased the risk of EH.
先前关于 ACE I/D、ACE2 G8790A 和 CYP11B2-344T/C 基因多态性与原发性高血压（EH）之间关系的研究结果并不一致。此外，很少有研究报道这些基因多态性与噪声暴露联合对 EH 的影响。本研究旨在探讨 ACE I/D、ACE2 G8790A 和 CYP11B2-344T/C 基因多态性与噪声对唐钢男性工人 EH 的联合和单独作用。
采用病例对照研究方法，于 2014 年 3 月至 2014 年 7 月选取唐钢公司 725 名男性工人为研究对象，测量其噪声暴露情况。采用 logistic 回归和交叉分析方法分析工人 EH 的基因-噪声相互作用效应。采用 GMDR 确定基因-噪声相互作用的最佳组合模型。
多因素 logistic 回归显示，噪声暴露增加了 EH 的发病风险，比值比（OR）为 1.52（95%可信区间 1.04-2.22）。ACE I/D DD 基因型携带者发生 EH 的风险是 II 基因型携带者的 1.99 倍（95%可信区间 1.14-3.51）。ACE2 G8790A 与 CYP11B2-344T/C 对 EH 存在负相加交互作用（U3= -2.221，P=0.026，S=0.128），ACE I/D 与 CYP11B2-344T/C 对原发性高血压存在正相乘交互作用（P=0.041）。此外，经过混杂因素调整后，GMDR 方法未发现有意义的基因-噪声交互作用模型。
ACE DD 基因型可能使男性易患 EH。同时携带 ACE I/D 的 DD 基因型和 CYP11B2-344T/C 的 TC 基因型会增加 EH 的发病风险。
