Li Jin, Wang Yan, Zeng Yawei, Wang Chao, Qi Wenjie
Department of Infectious Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. Corresponding author: Qi Wenjie, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2021 Dec;33(12):1519-1523. doi: 10.3760/cma.j.cn121430-20201120-00723.
Coagulation disorder or disseminated intravascular coagulation (DIC) is a clinicopathological syndrome, in which the imbalance between coagulation and fibrinolysis is the main pathogenesis, and systemic microthrombosis and systemic bleeding tendency are the main clinical manifestations. The clinical outcome is often the induction of systemic multiple organ dysfunction. As a common complication of sepsis, DIC significantly increases the mortality of septic patients. The coagulation disorder in sepsis is closely related to the inflammatory response of the body. Studying the mechanism of sepsis-related coagulation disorder will provide new possibilities for its early diagnosis and prognosis evaluation. This article reviews the latest research progress on the molecular mechanism of sepsis-related coagulation disorders in immunity and inflammation, in order to provide new possibilities for potential therapeutic targets.
凝血功能障碍或弥散性血管内凝血（DIC）是一种临床病理综合征，其中凝血与纤溶之间的失衡是主要发病机制，全身微血栓形成和全身出血倾向是主要临床表现。临床结局往往是诱发全身多器官功能障碍。作为脓毒症的常见并发症，DIC显著增加了脓毒症患者的死亡率。脓毒症中的凝血功能障碍与机体的炎症反应密切相关。研究脓毒症相关凝血功能障碍的机制将为其早期诊断和预后评估提供新的可能性。本文综述了脓毒症相关凝血功能障碍在免疫和炎症方面分子机制的最新研究进展，以便为潜在治疗靶点提供新的可能性。
