Department of Public Health, Erasmus MC, University Medical Centre, PO Box 2040, 3000CA, Rotterdam, the Netherlands; The Zeeland Public Health Service, PO Box 345, 4460AS, Goes, the Netherlands.
Department of Public Health, Erasmus MC, University Medical Centre, PO Box 2040, 3000CA, Rotterdam, the Netherlands; Department of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Centre Rotterdam, PO Box 2060, 3000CB, Rotterdam, the Netherlands.
Environ Res. 2022 Jun;209:112872. doi: 10.1016/j.envres.2022.112872. Epub 2022 Feb 5.
Air pollution may contribute to onset and progression of chronic diseases such as cardiovascular and respiratory diseases. Most studies have focused on the contribution of traffic-related exposure to PM or PM. Our aim was to investigate the association of different components of industry-related air pollution on the occurrence of chronic diseases. A register-based repeated cross-sectional study was conducted among 89,714 subjects (2012) with 536,599 annual observations (2012-2017) living in the vicinity of a large industrial area in the Netherlands. Information from the dispensed medication registration was linked with a dispersion model to characterize annual individual-level exposure of all subjects at place of residence. Associations between annual exposure (concentration and duration) to particulate matter (PM), nitrogen oxides (NO), sulphur dioxide (SO), and volatile organic compounds (VOC) with annual dispensed medication for cardiovascular diseases, respiratory diseases, diabetes mellitus, and inflammatory conditions were investigated by multivariate logistic regression analysis with generalized estimating equations (GEE) while controlling for confounders. Exposure to PM and to NO (per μg/m) were significantly associated with medication for cardiovascular diseases (OR 1.06, 95CI% 1.06-1.06 and OR 1.01, 95%CI 1.01-1.01 respectively). Exposures to PM and SO (per μg/m) were significantly associated with medication for inflammatory conditions (OR 1.05, 95%CI 1.00-1.09 and OR 1.07, 95%CI 1.01-1.14 respectively). Exposure to SO was inversely associated with respiratory diseases (OR 0.91, 95%CI 0.86-0.97). Except for inflammatory conditions, exposure duration (years) was significantly associated with the other three chronic diseases (OR varying from 1.01 to 1.03). This study indicates that specific air pollution components caused by industry may contribute to the occurrence of cardiovascular diseases, respiratory diseases, diabetes mellitus, and inflammatory conditions.
空气污染可能导致心血管和呼吸道等慢性疾病的发生和发展。大多数研究都集中在交通相关暴露于 PM 或 PM 对疾病的影响上。我们的目的是调查工业相关空气污染的不同成分对慢性疾病发生的关联。在荷兰一个大型工业区附近，进行了一项基于登记的重复横断面研究，共纳入 89714 名受试者（2012 年），共 536599 次年度观察（2012-2017 年）。从配药登记处获得的信息与一个扩散模型相关联，以描述所有受试者在居住地点的年度个人暴露水平。采用广义估计方程（GEE）控制混杂因素后，多元逻辑回归分析调查了每年暴露（浓度和持续时间）于颗粒物（PM）、氮氧化物（NO）、二氧化硫（SO）和挥发性有机化合物（VOC）与心血管疾病、呼吸道疾病、糖尿病和炎症性疾病的年度配药之间的关系。PM 和 NO（每μg/m）的暴露与心血管疾病的药物治疗显著相关（OR 1.06，95%CI%1.06-1.06 和 OR 1.01，95%CI 1.01-1.01）。PM 和 SO（每μg/m）的暴露与炎症性疾病的药物治疗显著相关（OR 1.05，95%CI 1.00-1.09 和 OR 1.07，95%CI 1.01-1.14）。SO 的暴露与呼吸道疾病呈负相关（OR 0.91，95%CI 0.86-0.97）。除炎症性疾病外，暴露时间（年）与其他三种慢性疾病显著相关（OR 从 1.01 到 1.03 不等）。本研究表明，工业产生的特定空气污染物成分可能导致心血管疾病、呼吸道疾病、糖尿病和炎症性疾病的发生。
