Maisin J R, Kondi-Tamba A, Mattelin G
Radiat Res. 1986 Feb;105(2):276-81.
Intravenous administration of 60 mg/kg of a polysaccharide (MNR, MNZ, GLP/BO4, GLP/BO5) significantly decreases the mortality of mice exposed to a single dose of X rays. The dose reduction factors (DRF) obtained for MNZ, MNR, GLP/BO4, and GLP/BO5 given intraperitoneally 15 min before exposure were 2.16, 1.93, 1.80, and 1.94, respectively. The DRF was not increased when MNZ or GLP/BO4 were combined with injection of AET before X-ray exposure. The LD50 for the CFUs exposed in vivo in mice was 1.13 Gy for the treated mice and 0.75 Gy for the nontreated mice. This corresponds to a DRF of 1.6. The DRF calculated from the slope is 1.27.
静脉注射60毫克/千克的多糖（MNR、MNZ、GLP/BO4、GLP/BO5）可显著降低接受单次X射线照射的小鼠的死亡率。在照射前15分钟腹腔注射MNZ、MNR、GLP/BO4和GLP/BO5所获得的剂量降低因子（DRF）分别为2.16、1.93、1.80和1.94。当MNZ或GLP/BO4与在X射线照射前注射AET联合使用时，DRF并未增加。经治疗的小鼠体内暴露的集落形成单位（CFU）的半数致死剂量（LD50）为1.13 Gy，未治疗的小鼠为0.75 Gy。这相当于DRF为1.6。根据斜率计算出的DRF为1.27。
