Berrut C, Curati W, de Gautard R, Widmann J J, Godin N, Loizeau E
Schweiz Med Wochenschr. 1986 Feb 15;116(7):215-8.
131 patients thought to have diffuse liver disease underwent ultrasonography and percutaneous liver biopsy. The ultrasonographic criteria examined were hepatic echogenicity compared to that of the renal cortex, homogeneity of hepatic parenchyma, and regularity of hepatic outline. On the basis of histologic examination of liver biopsies, several groups of pathologic lesions (not diagnostic entities) were established. Evaluation of ultrasound and histology was double blind. When the lobular architecture of the liver was respected histologically (normal liver, granulomatosis, siderosis, hepatitis), the ultrasound was normal in 86% of cases. The sensitivity of ultrasound was 0.9 for detection of fatty liver and 0.6 for cirrhosis. An abnormal ultrasound predicted structural modifications or a fatty liver in 93% of cases. Ultrasound proved incapable of differentiating between fatty liver and cirrhosis.
131例疑似患有弥漫性肝病的患者接受了超声检查和经皮肝活检。所检查的超声标准包括与肾皮质相比的肝脏回声、肝实质的均匀性以及肝脏轮廓的规则性。根据肝活检的组织学检查，确定了几组病理病变（而非诊断实体）。超声和组织学评估采用双盲法。当肝脏的小叶结构在组织学上保持完整时（正常肝脏、肉芽肿病、铁质沉着症、肝炎），86%的病例超声检查结果正常。超声检测脂肪肝的敏感性为0.9，检测肝硬化的敏感性为0.6。异常超声在93%的病例中预测存在结构改变或脂肪肝。超声无法区分脂肪肝和肝硬化。
