环状（烷基）（氨基）碳烯：亚铵前体的合成与结构性质。
Cyclic (Alkyl)(amino)carbenes: Synthesis of Iminium Precursors and Structural Properties.
机构信息
UCSD-CNRS Joint Research Laboratory (IRL 3555), Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, United States.
出版信息
J Org Chem. 2022 Mar 4;87(5):3511-3518. doi: 10.1021/acs.joc.1c03075. Epub 2022 Feb 8.
PMID:35133152
Abstract
Using readily available preallylated aldehydes, we report a simple and divergent synthesis of cyclic (alkyl)(amino)carbene (CAAC) iminium precursors. Using a combination of crystallographic data and steric maps, we further elaborate on the specific steric properties of CAAC ligands with respect to state-of-the-art phosphine and carbene ligands.
摘要
利用现成的预活化醛，我们报告了一种简单且多样化的环状（烷基）（氨基）卡宾（CAAC）亚胺前体的合成方法。结合晶体数据和空间位阻图，我们进一步详细阐述了 CAAC 配体相对于现有膦和卡宾配体的特定空间位阻性质。
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