School of Medicine, Universidad Autónoma de Ciudad Juárez, Chihuahua.
Ophthalmology Department, Hospital Juárez de México, Mexico City, Mexico.
Gac Med Mex. 2021;157(4):338-342. doi: 10.24875/GMM.M21000572.
Regional parafoveal vessel density changes have not been characterized in patients with type 2 diabetes without retinopathy.
To compare regional changes in vessel density between subjects without diabetes (group 1) and with diabetes without retinopathy (group 2).
Observacional, retrospective, cross-sectional, comparative study. Parafoveal vessel density by quadrants was compared between groups and between quadrants in each group; density of each quadrant and inner density were correlated, as well as the contribution of each quadrant to inner density (linear regression).
Thirty-four eyes were analyzed in group 1 and 38 in group 2; in the latter, inner vessel density (20.75 vs. 21.85, p = 0.021) and that of superior quadrants (21.05 vs. 21.75, p < 0.001), and nasal quadrants (20.95 vs. 21.50, p = 0.023) were lower. In the regression analysis, superior and nasal quadrants had the largest contribution to the change in inner vessel density in group 2 (b = 0.361 and b = 0.294, respectively).
Parafoveal inner vessel density decreases in diabetic patients without retinopathy at the expense of superior and nasal quadrants, which indicates that further evaluation is required for early microvascular disease to be detected.
尚未对无糖尿病性视网膜病变的 2 型糖尿病患者的区域性旁中心凹血管密度变化进行特征描述。
比较无糖尿病（第 1 组）和无糖尿病性视网膜病变（第 2 组）患者之间的血管密度的区域性变化。
观察性、回顾性、横断面、对比研究。比较了两组之间以及每组内各象限的旁中心凹血管密度；各象限的密度与内密度相关，以及各象限对内密度的贡献（线性回归）。
第 1 组分析了 34 只眼，第 2 组分析了 38 只眼；后者的内血管密度（20.75 比 21.85，p = 0.021）和上象限（21.05 比 21.75，p < 0.001）和鼻象限（20.95 比 21.50，p = 0.023）的密度较低。在回归分析中，上象限和鼻象限对第 2 组内血管密度变化的贡献最大（b = 0.361 和 b = 0.294）。
无糖尿病性视网膜病变的糖尿病患者的旁中心凹内血管密度降低，以上方和鼻侧象限为代价，这表明需要进一步评估以检测早期微血管病变。
