Center for Health Equity and Community Engagement Research, Mayo Clinic, Rochester, Minnesota.
Department of Family Medicine, Mayo Clinic, Rochester, Minnesota.
Cancer. 2022 Feb 15;128 Suppl 4(Suppl 4):883-891. doi: 10.1002/cncr.33954.
Multicancer screening is a promising approach to improving the detection of preclinical disease, but current technologies have limited ability to identify precursor or early stage lesions, and approaches for developing the evidentiary chain are unclear. Frameworks to enable development and evaluation from discovery through evidence of clinical effectiveness are discussed.
多癌种筛查是一种很有前途的方法,可以提高对临床前期疾病的检测,但目前的技术在识别前体或早期病变方面能力有限,开发证据链的方法也不清楚。本文讨论了从发现到临床有效性证据的开发和评估的框架。