Andresen J, Nielsen H E, Albertsen K
Acta Med Scand. 1986;219(1):99-104. doi: 10.1111/j.0954-6820.1986.tb03282.x.
Quantitative radiological measurements on the second left metacarpal bone were carried out in 23 patients with primary hyperparathyroidism, 22 corticosteroid-treated patients with polymyalgia rheumatica and 40 renal transplant recipients treated with prednisone and azathioprine. Women with primary hyperparathyroidism and corticosteroid-treated women showed significantly decreased mean values of metacarpal bone compared to normal controls, probably due to a higher bone resorption than formation at the endosteal surface. Bone loss was more pronounced in corticosteroid-treated women than in women with primary hyperparathyroidism, partly due to age difference. In renal transplant recipients, bone loss took place during the initial period after renal transplantation, probably due to increased endosteal bone resorption. During this period a periosteal new bone formation took place in female renal transplant recipients. The quantitative radiological measurements make it possible to determine whether bone loss is due to a higher ratio of bone resorption than of bone formation at the periosteal and/or endosteal surface.
对23例原发性甲状旁腺功能亢进患者、22例接受皮质类固醇治疗的风湿性多肌痛患者以及40例接受泼尼松和硫唑嘌呤治疗的肾移植受者的左手第二掌骨进行了放射学定量测量。原发性甲状旁腺功能亢进的女性患者以及接受皮质类固醇治疗的女性患者，其掌骨平均值与正常对照组相比显著降低，这可能是由于骨内膜表面的骨吸收高于骨形成。皮质类固醇治疗的女性患者的骨质流失比原发性甲状旁腺功能亢进的女性患者更明显，部分原因是年龄差异。在肾移植受者中，骨质流失发生在肾移植后的初期，可能是由于骨内膜骨吸收增加。在此期间，女性肾移植受者出现了骨膜新骨形成。放射学定量测量能够确定骨质流失是否是由于骨膜和/或骨内膜表面的骨吸收与骨形成的比例较高所致。
