早产儿心脏肥大与胰岛素治疗：二者是否存在关联？
Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?
机构信息
Neonatal Intensive Care Unit and Human Milk Bank, Department of Neonatology, Bambino Gesù Children's Hospital, IRCSS, Rome, Italy.
Pediatrics Department, Umberto I Hospital, Sapienza University, Rome, Italy.
出版信息
Ital J Pediatr. 2022 Feb 8;48(1):24. doi: 10.1186/s13052-022-01216-7.
Abstract
BACKGROUND
Hypertrophic cardiomyopathy (HCM) in newborns is a rare condition with heterogeneous etiologies. While the relationship between hyperinsulinism and cardiac hypertrophy (CH) is known, hyperinsulinism has not been reported as cause of HCM.
CASE PRESENTATION
We report the case of cardiac hypertrophy (CH) in an Extremely Low Birth Weight (ELBW) infant; this patient underwent insulin therapy after the onset of persistent hyperglycemia due to parenteral nutrition (PN), supporting the hypothesis of a role of iatrogenic hyperinsulinemia in the development of HCM.
CONCLUSIONS
The present case underlines the importance of a close cardiological follow-up in infants undergoing insulin infusion for an alteration in the glucose metabolism.
摘要
背景
新生儿肥厚型心肌病（HCM）是一种病因多样的罕见病症。虽然已知高胰岛素血症与心肌肥厚（CH）之间存在关联，但高胰岛素血症尚未被报道为 HCM 的病因。
病例介绍
我们报告了一例极低出生体重（ELBW）婴儿的心肌肥厚（CH）病例；该患者在因肠外营养（PN）而出现持续性高血糖后开始接受胰岛素治疗，这支持了医源性高胰岛素血症在 HCM 发展中的作用假说。
结论
本病例强调了在接受胰岛素输注以改变葡萄糖代谢的婴儿中进行密切心脏随访的重要性。
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