Josselson J, Sadler J H
Am J Med. 1986 Mar;80(3):545-6. doi: 10.1016/0002-9343(86)90741-2.
Glycosuria, hyperglycemia, and nephrotic-range proteinuria developed in a 68-year-old patient after clonidine was added to a stable antihypertensive regimen, which included metoprolol, of three years' duration. He later became glucose-intolerant with fasting hyperglycemia. Clonidine has been reported to transiently impair glucose tolerance. Persistent diabetes in a previously normoglycemic patient following clonidine has not been reported, and it supports the possibility that clonidine and metoprolol may have additive effects in suppressing endogenous insulin secretion.
在一名68岁患者中，在其持续三年的稳定降压方案（包括美托洛尔）中添加可乐定后，出现了糖尿、高血糖和肾病范围的蛋白尿。他后来出现了空腹高血糖的糖耐量不耐受情况。据报道，可乐定可短暂损害糖耐量。此前血糖正常的患者在服用可乐定后出现持续性糖尿病的情况尚未见报道，这支持了可乐定和美托洛尔在抑制内源性胰岛素分泌方面可能具有相加作用的可能性。
