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与正常眼睛相比，药物性散瞳对有滤过泡的眼睛眼压的影响：一项初步研究。

Effect of Pharmacological Mydriasis on the Intraocular Pressure in Eyes with Filtering Blebs Compared to Normal Eyes: A Pilot Study.

作者信息

Gharieb Ibrahim Hani M

机构信息

Ophthalmology Department, Ain Shams University, Cairo, Egypt.

出版信息

Clin Ophthalmol. 2022 Feb 1;16:231-237. doi: 10.2147/OPTH.S348365. eCollection 2022.

DOI:10.2147/OPTH.S348365
PMID:35136349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8817738/
Abstract

AIM

To test the effect of pharmacological mydriasis on intraocular pressure (IOP) in eyes with functioning blebs compared with normal eyes.

PATIENTS AND METHODS

The cross-sectional study included 39 eyes, of which 19 eyes had filtering trabeculectomy blebs (group A), and 20 eyes with no previous surgeries (group B). IOP was measured using the Goldmann applanation tonometer before, and 30 min after the application of tropicamide 1% eye drops.

RESULTS

In group A eyes, the IOP level changed from 13.68 ± 3.4 mmHg before pupillary dilatation, to achieve a level of 11.95 ± 3.03 mmHg following mydriasis, with an average IOP drop of 1.73 mmHg (p < 0.0001). On the other hand, the pre-dilatation IOP in group B eyes was 15.9 ± 3.00 mmHg, had increased after mydriasis to 18.4 ± 2.9 mmHg, with an average rise of 2.5 mmHg (p < 0.0001). The difference in IOP change following mydriasis between both groups was significant (p < 0.0001).

CONCLUSION

Surprisingly, pharmacological pupillary dilatation resulted in a reduction of IOP in eyes with successful trabeculectomy, which is different from the usual effect of raising the IOP as in the control group. This effect has not been previously studied.

摘要

目的

测试药物性散瞳对有功能性滤过泡的眼睛与正常眼睛眼压（IOP）的影响。

患者与方法

这项横断面研究纳入了39只眼睛，其中19只眼睛有小梁切除术滤过泡（A组），20只眼睛未曾接受过手术（B组）。在使用1%托吡卡胺滴眼液前及用药后30分钟，使用Goldmann压平眼压计测量眼压。

结果

在A组眼睛中，眼压水平从散瞳前的13.68±3.4 mmHg，散瞳后降至11.95±3.03 mmHg，平均眼压下降1.73 mmHg（p<0.0001）。另一方面，B组眼睛散瞳前眼压为15.9±3.00 mmHg，散瞳后升至18.4±2.9 mmHg，平均升高2.5 mmHg（p<0.0001）。两组散瞳后眼压变化的差异具有统计学意义（p<0.0001）。

结论

令人惊讶的是，药物性散瞳导致小梁切除术成功的眼睛眼压降低，这与对照组中通常升高眼压的效果不同。此前尚未对这种效应进行过研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e00/8817738/27c6110e952d/OPTH-16-231-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e00/8817738/6057947fc2cc/OPTH-16-231-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e00/8817738/efa1949950aa/OPTH-16-231-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e00/8817738/27c6110e952d/OPTH-16-231-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e00/8817738/6057947fc2cc/OPTH-16-231-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e00/8817738/efa1949950aa/OPTH-16-231-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e00/8817738/27c6110e952d/OPTH-16-231-g0003.jpg

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