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Clin Infect Dis. 2022 Sep 10;75(4):710-714. doi: 10.1093/cid/ciac097.
2
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Not all carbapenem-resistant Pseudomonas aeruginosa strains are alike: tailoring antibiotic therapy based on resistance mechanisms.并非所有耐碳青霉烯铜绿假单胞菌菌株都相同：根据耐药机制调整抗生素治疗。
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Real-world use of imipenem/cilastatin/relebactam for the treatment of KPC-producing complex and difficult-to-treat resistance (DTR) infections: a single-center preliminary experience.亚胺培南/西司他丁/瑞来巴坦在治疗产KPC的复杂且难治性耐药（DTR）感染中的真实世界应用：单中心初步经验
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本文引用的文献

1
Emergence of Resistance to Novel Cephalosporin-β-Lactamase Inhibitor Combinations through the Modification of the Pseudomonas aeruginosa MexCD-OprJ Efflux Pump.通过修饰铜绿假单胞菌 MexCD-OprJ 外排泵，新型头孢菌素-β-内酰胺酶抑制剂组合出现耐药性。
Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0008921. doi: 10.1128/AAC.00089-21.
2
The Building Blocks of Antimicrobial Resistance in : Implications for Current Resistance-Breaking Therapies.抗菌药物耐药性的构成要素：对当前抗耐药性治疗的启示
Front Cell Infect Microbiol. 2021 Apr 16;11:665759. doi: 10.3389/fcimb.2021.665759. eCollection 2021.
3
Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa following Treatment-Emergent Resistance to Ceftolozane-Tazobactam.治疗中出现对头孢洛扎他唑巴坦耐药后，多重耐药铜绿假单胞菌的易感性。
Antimicrob Agents Chemother. 2021 May 18;65(6). doi: 10.1128/AAC.00084-21.
4
Pseudomonas aeruginosa epidemic high-risk clones and their association with horizontally-acquired β-lactamases: 2020 update.铜绿假单胞菌流行高危克隆及其与水平获得性β-内酰胺酶的关系：2020 年更新。
Int J Antimicrob Agents. 2020 Dec;56(6):106196. doi: 10.1016/j.ijantimicag.2020.106196. Epub 2020 Oct 9.
5
Modifiable Risk Factors for the Emergence of Ceftolozane-tazobactam Resistance.可改变的头孢洛扎他唑巴坦耐药出现的危险因素。
Clin Infect Dis. 2021 Dec 6;73(11):e4599-e4606. doi: 10.1093/cid/ciaa1306.
6
A Randomized, Double-blind, Multicenter Trial Comparing Efficacy and Safety of Imipenem/Cilastatin/Relebactam Versus Piperacillin/Tazobactam in Adults With Hospital-acquired or Ventilator-associated Bacterial Pneumonia (RESTORE-IMI 2 Study).一项比较亚胺培南/西司他丁/雷巴他定与哌拉西林/他唑巴坦治疗成人医院获得性或呼吸机相关性细菌性肺炎疗效和安全性的随机、双盲、多中心试验（RESTORE-IMI 2 研究）。
Clin Infect Dis. 2021 Dec 6;73(11):e4539-e4548. doi: 10.1093/cid/ciaa803.
7
In vitro dynamics and mechanisms of resistance development to imipenem and imipenem/relebactam in Pseudomonas aeruginosa.铜绿假单胞菌对亚胺培南和亚胺培南/雷巴他定耐药性的体外动力学和机制。
J Antimicrob Chemother. 2020 Sep 1;75(9):2508-2515. doi: 10.1093/jac/dkaa206.
8
Activity of Imipenem-Relebactam against a Large Collection of Pseudomonas aeruginosa Clinical Isolates and Isogenic β-Lactam-Resistant Mutants.亚胺培南-雷巴坦对大量铜绿假单胞菌临床分离株和同源β-内酰胺耐药突变株的活性。
Antimicrob Agents Chemother. 2020 Jan 27;64(2). doi: 10.1128/AAC.02165-19.
9
RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections.RESTORE-IMI 1 研究：一项比较亚胺培南/雷巴他定与多黏菌素 E 联合亚胺培南治疗对亚胺培南耐药的细菌感染患者的疗效和安全性的多中心、随机、双盲试验。
Clin Infect Dis. 2020 Apr 15;70(9):1799-1808. doi: 10.1093/cid/ciz530.
10
In vitro studies evaluating the activity of imipenem in combination with relebactam against Pseudomonas aeruginosa.评价亚胺培南与雷巴他定联合应用对铜绿假单胞菌活性的体外研究。
BMC Microbiol. 2019 Jul 4;19(1):150. doi: 10.1186/s12866-019-1522-7.

多药耐药铜绿假单胞菌肺炎治疗后亚胺培南-雷巴他定耐药的演变。

Evolution of Imipenem-Relebactam Resistance Following Treatment of Multidrug-Resistant Pseudomonas aeruginosa Pneumonia.

机构信息

Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

XDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

出版信息

Clin Infect Dis. 2022 Sep 10;75(4):710-714. doi: 10.1093/cid/ciac097.

DOI:10.1093/cid/ciac097
PMID:35136967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9890448/
Abstract

We report the emergence of imipenem-relebactam nonsusceptible Pseudomonas aeruginosa in 5 patients treated for nosocomial pneumonia for 10-28 days. Genome sequence analysis identified treatment-emergent mutations in MexAB-OprM and/or MexEF-OprN efflux operons that arose independently in each patient across distinct P. aeruginosa sequence types. Testing with efflux-inhibitor PAβN restored imipenem-relebactam susceptibility.

摘要

我们报告了 5 例住院肺炎患者在接受治疗 10-28 天后出现对亚胺培南-雷巴他定不敏感的铜绿假单胞菌。基因组序列分析鉴定出 MexAB-OprM 和/或 MexEF-OprN 外排操纵子在每个患者中独立出现的治疗后突变，这些患者跨越不同的铜绿假单胞菌序列类型。用外排抑制剂 PAβN 进行测试恢复了亚胺培南-雷巴他定的敏感性。