• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2021 年春夏德国侵袭性肺炎球菌病再现。

Reemergence of Invasive Pneumococcal Disease in Germany During the Spring and Summer of 2021.

机构信息

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA.

German National Reference Center for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany.

出版信息

Clin Infect Dis. 2022 Sep 30;75(7):1149-1153. doi: 10.1093/cid/ciac100.

DOI:10.1093/cid/ciac100
PMID:35136983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9383454/
Abstract

BACKGROUND

The incidence of invasive pneumococcal disease (IPD) decreased worldwide in 2020 and the first quarter of 2021, concurrent with nonpharmaceutical interventions (NPIs) intended to stymie transmission of SARS-CoV-2. In 2021, the stringency of these NPI strategies has varied. We investigated age- and serotype-specific variations in IPD case counts in Germany in 2020-2021.

METHODS

IPD cases through 30 November 2021 were stratified by age group, serotype, or geographic location. IPD surveillance data in 2020-2021 were compared with (1) IPD surveillance data from 2015-2019, (2) mobility data during 2020 and 2021, and (3) NPI stringency data in 2020 and 2021.

RESULTS

IPD incidence began to return toward baseline among children 0-4 years old in April 2021 and exceeded baseline by June 2021 (a 9% increase over the average monthly values for 2015-2019). Children aged 5-14 years and adults aged 15-34 or ≥80 years showed increases in IPD cases that exceeded baseline values starting in July 2021, with increases also starting in spring 2021. The age distribution and proportion of vaccine-serotype IPD remained comparable to those in previous years, despite lower overall case counts in 2020 and 2021. The percentage change in IPD incidence compared with the previous 5 years was correlated with changes in mobility and with NPI stringency.

CONCLUSIONS

IPD levels began to return to and exceed seasonal levels in spring and summer 2021 in Germany, following sharp declines in 2020 that coincided with NPIs related to the coronavirus disease 2019 pandemic. Proportions of vaccine serotypes remained largely consistent throughout 2020-2021.

摘要

背景

2020 年及 2021 年第一季度，全球侵袭性肺炎球菌病（IPD）发病率下降，与此同时，旨在阻止严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）传播的非药物干预措施（NPI）也在实施。2021 年，这些 NPI 策略的严格程度有所不同。我们调查了德国 2020-2021 年 IPD 病例数量的年龄和血清型特异性变化。

方法

通过年龄组、血清型或地理位置对 2021 年 11 月 30 日前的 IPD 病例进行分层。将 2020-2021 年的 IPD 监测数据与（1）2015-2019 年的 IPD 监测数据、（2）2020 年和 2021 年的流动数据以及（3）2020 年和 2021 年的 NPI 严格程度数据进行了比较。

结果

2021 年 4 月，0-4 岁儿童的 IPD 发病率开始恢复到基线水平，2021 年 6 月超过基线（比 2015-2019 年的平均每月值高 9%）。2021 年 7 月，5-14 岁儿童和 15-34 岁或≥80 岁的成年人的 IPD 病例开始超过基线值，2021 年春季也开始出现这种情况。尽管 2020 年和 2021 年的总病例数较低，但年龄分布和疫苗血清型 IPD 的比例与前几年相似。与前 5 年相比，IPD 发病率的变化百分比与流动变化和 NPI 严格程度相关。

结论

德国的 IPD 水平在 2020 年急剧下降后，于 2021 年春季和夏季开始回升并超过季节性水平，这与 2019 年冠状病毒病（COVID-19）大流行期间与 NPI 相关的下降趋势一致。2020-2021 年期间，疫苗血清型的比例基本保持一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e74/9525083/e6ec7a00d098/ciac100_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e74/9525083/293de04c8c10/ciac100_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e74/9525083/e6ec7a00d098/ciac100_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e74/9525083/293de04c8c10/ciac100_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e74/9525083/e6ec7a00d098/ciac100_fig2.jpg

相似文献

1
Reemergence of Invasive Pneumococcal Disease in Germany During the Spring and Summer of 2021.2021 年春夏德国侵袭性肺炎球菌病再现。
Clin Infect Dis. 2022 Sep 30;75(7):1149-1153. doi: 10.1093/cid/ciac100.
2
Reduction in the incidence of invasive pneumococcal disease after general vaccination with 7-valent pneumococcal conjugate vaccine in Germany.在德国使用7价肺炎球菌结合疫苗进行普遍接种后侵袭性肺炎球菌疾病发病率的降低。
Vaccine. 2009 Jun 24;27(31):4136-41. doi: 10.1016/j.vaccine.2009.04.057. Epub 2009 May 9.
3
Association of Nonpharmaceutical Interventions During the COVID-19 Pandemic With Invasive Pneumococcal Disease, Pneumococcal Carriage, and Respiratory Viral Infections Among Children in France.新型冠状病毒肺炎大流行期间非药物干预措施与法国儿童侵袭性肺炎球菌病、肺炎球菌携带和呼吸道病毒感染的相关性。
JAMA Netw Open. 2022 Jun 1;5(6):e2218959. doi: 10.1001/jamanetworkopen.2022.18959.
4
Four years of universal pneumococcal conjugate infant vaccination in Germany: impact on incidence of invasive pneumococcal disease and serotype distribution in children.德国开展四年的通用型肺炎球菌结合疫苗儿童免疫接种：对侵袭性肺炎球菌病发病率和儿童血清型分布的影响。
Vaccine. 2012 Aug 31;30(40):5880-5. doi: 10.1016/j.vaccine.2012.06.068. Epub 2012 Jul 4.
5
Changing serotypes causing childhood invasive pneumococcal disease: Massachusetts, 2001-2007.导致儿童侵袭性肺炎球菌病的血清型变化：马萨诸塞州，2001-2007 年。
Pediatr Infect Dis J. 2010 Apr;29(4):289-93. doi: 10.1097/INF.0b013e3181c15471.
6
Prompt effect of replacing the 7-valent pneumococcal conjugate vaccine with the 13-valent vaccine on the epidemiology of invasive pneumococcal disease in Norway.13 价肺炎球菌结合疫苗替代 7 价肺炎球菌结合疫苗对挪威侵袭性肺炎球菌病流行病学的影响。
Vaccine. 2013 Dec 16;31(52):6232-8. doi: 10.1016/j.vaccine.2013.10.032. Epub 2013 Oct 29.
7
Regional variations in serotype distribution and vaccination status in children under six years of age with invasive pneumococcal disease in Germany.德国 6 岁以下侵袭性肺炎球菌病患儿中血清型分布和疫苗接种状况的地域差异。
PLoS One. 2019 Jan 9;14(1):e0210278. doi: 10.1371/journal.pone.0210278. eCollection 2019.
8
Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany.婴儿肺炎球菌结合疫苗对德国儿童和成人侵袭性肺炎球菌疾病血清型分布的影响。
PLoS One. 2015 Jul 1;10(7):e0131494. doi: 10.1371/journal.pone.0131494. eCollection 2015.
9
Geographic variation in invasive pneumococcal disease following pneumococcal conjugate vaccine introduction in the United States.美国引入肺炎球菌结合疫苗后侵袭性肺炎球菌病的地域差异。
Clin Infect Dis. 2011 Jul 15;53(2):137-43. doi: 10.1093/cid/cir326.
10
Surveillance for invasive pneumococcal disease during 2000-2005 in a population of children who received 7-valent pneumococcal conjugate vaccine.对2000年至2005年期间接种7价肺炎球菌结合疫苗的儿童群体进行侵袭性肺炎球菌疾病监测。
Pediatr Infect Dis J. 2007 Sep;26(9):771-7. doi: 10.1097/INF.0b013e318124a494.

引用本文的文献

1
Incidence, etiologies, and outcomes of severe pediatric community-acquired empyema before and after the pandemic: an Italian multicentric study.大流行前后严重儿童社区获得性脓胸的发病率、病因及结局：一项意大利多中心研究
Eur J Pediatr. 2025 Sep 4;184(9):594. doi: 10.1007/s00431-025-06411-2.
2
Elixhauser Comorbidity Measure and Charlson Comorbidity Index in Predicting the Death of Spanish Inpatients with Diabetes and Invasive Pneumococcal Disease.Elixhauser共病测量法和Charlson共病指数在预测西班牙糖尿病合并侵袭性肺炎球菌病住院患者死亡中的应用
Microorganisms. 2025 Jul 11;13(7):1642. doi: 10.3390/microorganisms13071642.
3
Temporal changes in pneumococcal carriage among childcare-attending children during the COVID-19 pandemic in the Greater New Haven Area, USA.
美国大纽黑文地区新冠疫情期间参加儿童保育服务儿童的肺炎球菌携带情况的时间变化
Res Sq. 2025 Jun 23:rs.3.rs-6665081. doi: 10.21203/rs.3.rs-6665081/v1.
4
Serotype distribution of invasive and non-invasive pneumococcal disease in children ≤5 years of age following the introduction of 10- and 13-valent pneumococcal conjugate vaccines in infant national immunization programs: a systematic literature review.在国家婴幼儿免疫规划中引入10价和13价肺炎球菌结合疫苗后，5岁及以下儿童侵袭性和非侵袭性肺炎球菌疾病的血清型分布：一项系统文献综述
Front Public Health. 2025 May 30;13:1544359. doi: 10.3389/fpubh.2025.1544359. eCollection 2025.
5
Serotype distribution of invasive and non-invasive pneumococcal disease in adults ≥65 years of age following the introduction of 10- and 13-valent pneumococcal conjugate vaccines in infant national immunization programs: a systematic literature review.在婴儿国家免疫规划中引入10价和13价肺炎球菌结合疫苗后≥65岁成年人侵袭性和非侵袭性肺炎球菌疾病的血清型分布：一项系统文献综述
Front Public Health. 2025 May 30;13:1544331. doi: 10.3389/fpubh.2025.1544331. eCollection 2025.
6
A rise in severe necrotizing fasciitis- another consequence of the COVID-19 pandemic?严重坏死性筋膜炎的增加——这是新冠疫情的另一个后果吗？
Infection. 2025 Jun 4. doi: 10.1007/s15010-025-02564-2.
7
Temporal changes in pneumococcal carriage among childcare-attending children during the COVID-19 pandemic in the Greater New Haven Area, USA.美国大纽黑文地区新冠疫情期间参加儿童保育服务儿童的肺炎球菌携带情况的时间变化。
medRxiv. 2025 May 16:2025.05.15.25327698. doi: 10.1101/2025.05.15.25327698.
8
Pediatric Rotavirus Hospitalization Rates in the Military Health System Before and During the COVID-19 Pandemic.新冠疫情之前及期间军事医疗系统中的小儿轮状病毒住院率
Vaccines (Basel). 2025 May 2;13(5):492. doi: 10.3390/vaccines13050492.
9
Epidemiological Impact of Increasing Vaccination Coverage Rate and Re-Vaccination on Pneumococcal Disease in Older Adults in Germany.提高疫苗接种覆盖率和再次接种对德国老年人肺炎球菌疾病的流行病学影响
Vaccines (Basel). 2025 Apr 28;13(5):475. doi: 10.3390/vaccines13050475.
10
Changes in the incidence, viral coinfection pattern and outcomes of pneumococcal hospitalizations during and after the COVID-19 pandemic.2019冠状病毒病大流行期间及之后肺炎球菌住院的发病率、病毒合并感染模式及转归变化
Pneumonia (Nathan). 2025 Apr 25;17(1):9. doi: 10.1186/s41479-025-00164-0.