regulated by miR-139-3p regulates the progression of hepatocellular carcinoma cells.

This study mainly explores how impacts the progression of hepatocellular carcinoma (HCC). Mature miRNA and mRNA expression data along with the clinical data of HCC were provided by The Cancer Genome Atlas to mine differentially expressed miRNAs and mRNAs. Expression levels of and miR-139-3p in HCC were tested through quantitative real-time PCR. How and miR-139-3p impacted HCC cell activities were detected by Transwell, wound healing and cell proliferation approaches. Whether miR-139-3p could bind to was detected by dual-luciferase assay. This investigation found evidently high levels of in both HCC tissue and cells and its marked association with poor prognosis. Overexpression of could significantly promote the behaviors of HCC cells. In addition, poorly expressed miR-139-3p was inversely associated with . Dual-luciferase method also proved the association. The rescue experiment showed that miR-139-3p regulated cell behaviors in HCC through targeting . Highly expressed was mediated by miR-139-3p to modulate cell behaviors in HCC. It is assumed that is a possible target of HCC for cancer therapy purposes.