内源性大麻素与成瘾记忆：与甲基苯丙胺/吗啡滥用的相关性。
Endocannabinoids and addiction memory: Relevance to methamphetamine/morphine abuse.
作者信息
Alizamini Mirmohammadali Mirramezani, Li Yonghui, Zhang Jian-Jun, Liang Jing, Haghparast Abbas
机构信息
CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
出版信息
World J Biol Psychiatry. 2022 Dec;23(10):743-763. doi: 10.1080/15622975.2022.2039408. Epub 2022 Mar 4.
AIM
This review aims to summarise the role of endocannabinoid system (ECS), incluing cannabinoid receptors and their endogenous lipid ligands in the modulation of methamphetamine (METH)/morphine-induced memory impairments.
METHODS
Here, we utilized the results from researches which have investigated regulatory role of ECS (including cannabinoid receptor agonists and antagonists) on METH/morphine-induced memory impairments.
RESULTS
Among the neurotransmitters, glutamate and dopamine seem to play a critical role in association with the ECS to heal the drug-induced memory damages. Also, the amygdala, hippocampus, and prefrontal cortex are three important brain regions that participate in both drug addiction and memory task processes, and endocannabinoid neurotransmission have been investigated.
CONCLUSION
ECS can be regarded as a treatment for the side effects of METH and morphine, and their memory-impairing effects.
目的
本综述旨在总结内源性大麻素系统（ECS），包括大麻素受体及其内源性脂质配体在调节甲基苯丙胺（METH）/吗啡诱导的记忆损伤中的作用。
方法
在此，我们利用了研究结果，这些研究调查了ECS（包括大麻素受体激动剂和拮抗剂）对METH/吗啡诱导的记忆损伤的调节作用。
结果
在神经递质中，谷氨酸和多巴胺似乎在与ECS相关联以修复药物诱导的记忆损伤方面发挥关键作用。此外，杏仁核、海马体和前额叶皮质是参与药物成瘾和记忆任务过程的三个重要脑区，并且已经对内源性大麻素神经传递进行了研究。
结论
ECS可被视为治疗METH和吗啡副作用及其记忆损伤作用的方法。
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