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[勘误] miR-29b过表达通过调控SIRT1/PGC-1α信号通路诱导耳蜗毛细胞凋亡:对年龄相关性听力损失的影响

[Corrigendum] miR‑29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC‑1α signaling: Implications for age‑related hearing loss.

作者信息

Xue Tao, Wei Li, Zha Ding-Jun, Qiu Jian-Hua, Chen Fu-Quan, Qiao Li, Qiu Yang

机构信息

Department of Otolaryngology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710003, P.R. China.

Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710003, P.R. China.

出版信息

Int J Mol Med. 2022 Apr;49(4). doi: 10.3892/ijmm.2022.5100. Epub 2022 Feb 9.

DOI:10.3892/ijmm.2022.5100
PMID:35137916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8846939/
Abstract

Subsequently to the publication of the above paper, an interested reader drew to the authors' attention that the bar charts shown in Fig. 4A and B, which were intending to have shown the RT‑qPCR and western blot analyses of SIRT1 and PGC‑1α in HEI‑OC1 cells, respectively, under different experimental conditions were apparently identical. Similarly, in Fig. 5, the histograms shown in Fig. 5C and D, which were intending to have shown the RT‑qPCR and western blot analyses, respectively, of SIRT1 and PGC‑1α in HEI‑OC1 cells subjected to different treatments were also apparently identical. The authors have re‑examined their data, and realize that the data properly belonging to the protein expression levels had been wrongly used to show the mRNA levels, and therefore Figs. 4A and 5C were presented incorrectly in these figures. The revised versions of Figs. 4 and 5, containing the correct data for the RT‑qPCR experiments in Figs. 4A and 5C, are shown on the next page. These errors did not affect the major conclusions reported in the paper. All the authors have agreed to this corrigendum, and thank the Editor of for allowing them the opportunity to publish this. The authors regret these errors went unnoticed during the compilation of the figures in question, and apologize to the readership for any confusion that this may have caused. [the original article was published in 38: 1387‑1394, 20186 DOI: 10.3892/ijmm.2016.2735].

摘要

在上述论文发表之后,一位感兴趣的读者提请作者注意,图4A和B中所示的柱状图显然是相同的,这两张图原本分别打算展示在不同实验条件下HEI-OC1细胞中SIRT1和PGC-1α的逆转录定量聚合酶链反应(RT-qPCR)和蛋白质免疫印迹分析结果。同样,在图5中,图5C和D所示的直方图也显然是相同的,这两张图原本分别打算展示经过不同处理的HEI-OC1细胞中SIRT1和PGC-1α的RT-qPCR和蛋白质免疫印迹分析结果。作者重新检查了他们的数据,意识到本应属于蛋白质表达水平的数据被错误地用于展示mRNA水平,因此图4A和5C在这些图中的呈现是不正确的。图4和图5的修订版本在下一页,其中包含了图4A和5C中RT-qPCR实验的正确数据。这些错误并未影响该论文报道的主要结论。所有作者都同意这份勘误,并感谢[期刊名称]编辑给予他们发表此勘误的机会。作者对在编制相关图表过程中未注意到这些错误表示遗憾,并就可能由此给读者造成的任何困惑向读者致歉。[原文发表于《国际分子医学杂志》38: 1387 - 1394, 20186 DOI: 10.3892/ijmm.2016.2735]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b9/8846939/69e813748cdd/IJMM-49-04-05100-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b9/8846939/100d76d9249a/IJMM-49-04-05100-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b9/8846939/69e813748cdd/IJMM-49-04-05100-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b9/8846939/100d76d9249a/IJMM-49-04-05100-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64b9/8846939/69e813748cdd/IJMM-49-04-05100-g01.jpg

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