Clinical Department of Nuclear Medicine and Radiation Protection, University Hospital Centre Zagreb.
The University of Zagreb School of Medicine, Zagreb, Croatia.
Nucl Med Rev Cent East Eur. 2022;25(1):66-67. doi: 10.5603/NMR.a2022.0013.
We present a case report of incidental detection of breast cancer in a female patient referred for 18F-fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) due to primary hyperparathyroidism. This imaging method was recently shown as more sensitive for the detection of metabolically hyperactive parathyroid glands than neck ultrasound and (2-metoksyizobutyloizonitryl labeled with technetium-99m) [99mTc]MIBI. Increased accumulation of FCH was found in the hyperactive parathyroid gland and unexpectedly in the right breast lesion. The surgery confirmed parathyroid adenoma. One month later right upper medial quadrantectomy confirmed breast carcinoma - a combination of invasive ductal carcinoma and intracystic papillary breast carcinoma. To the best of our knowledge, this is the first reporting of simultaneous detection of parathyroid adenoma and breast cancer by using 18F-fluorocholine PET/CT.
我们报告了一例女性患者因原发性甲状旁腺功能亢进症而接受 18F-氟胆碱（FCH）正电子发射断层扫描/计算机断层扫描（PET/CT）检查时偶然发现乳腺癌的病例。最近的研究表明，与颈部超声和（2-甲氧基异丁基异腈标记锝-99m）[99mTc]MIBI 相比，这种成像方法对于检测代谢活跃的甲状旁腺更敏感。在功能亢进的甲状旁腺中发现了 FCH 的过度积聚，而在右侧乳房病变中则出乎意料地发现了 FCH 的过度积聚。手术证实为甲状旁腺腺瘤。一个月后，右上内侧象限切除术证实为乳腺癌——浸润性导管癌和囊内乳头状乳腺癌的组合。据我们所知，这是首例使用 18F-氟胆碱 PET/CT 同时检测甲状旁腺腺瘤和乳腺癌的报道。
