Department of Hematology, Level 5, Research Block A.
Department of Internal Medicine, Level 4, Nehru Hospital, Postgraduate Institute of Medical Education & Research, Chandigarh, Punjab, India.
Blood Coagul Fibrinolysis. 2022 Mar 1;33(2):113-118. doi: 10.1097/MBC.0000000000001114.
The association of the fibrinolytic markers with deep vein thrombosis (DVT) is still a matter of debate. The present study aimed to investigate the association between fibrinolytic markers and DVT. This observational study recruited 52 adult cases with lower limb DVT and 52 healthy adult volunteers as controls. The quantitative determination of plasminogen activator inhibitor-1 (PAI-1), plasminogen, thrombin activable fibrinolysis inhibitor (TAFI), tissue plasminogen activator (tPA) and α2-antiplasmin (α2-AP) was performed by ELISA. TAFI, plasminogen and t-PA were significantly higher in cases than controls and PAI-1 was significantly lower in cases than controls. In addition, TAFI, plasminogen and t-PA levels were significantly increased in unprovoked and idiopathic DVT cases than controls. The present study suggests that the fibrinolytic markers tested in patients with a remote history of DVT are different than in individuals with no history of DVT and, with further study, may prove useful as screening assays for DVT risk.
纤溶标志物与深静脉血栓形成（DVT）的关系仍存在争议。本研究旨在探讨纤溶标志物与 DVT 的关系。该观察性研究招募了 52 例下肢 DVT 成年患者和 52 名健康成年志愿者作为对照组。通过 ELISA 定量测定纤溶酶原激活物抑制剂-1（PAI-1）、纤溶酶原、凝血酶激活的纤溶抑制物（TAFI）、组织型纤溶酶原激活物（tPA）和α2-抗纤溶酶（α2-AP）。与对照组相比，病例组的 TAFI、纤溶酶原和 t-PA 明显升高，而 PAI-1 明显降低。此外，与对照组相比，无诱因和特发性 DVT 病例的 TAFI、纤溶酶原和 t-PA 水平显著升高。本研究表明，在有 DVT 病史的患者中检测到的纤溶标志物与无 DVT 病史的个体不同，进一步研究可能有助于作为 DVT 风险的筛查试验。
