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成人高磷酸酶血症。临床、影像学和组织形态计量学 findings 以及与经典佩吉特病的比较。 注:原文中“findings”直接保留英文,可能是特定医学术语或有特定含义,在准确翻译医学文献时,有时会保留一些英文术语以确保专业性和准确性。若要更准确翻译,可补充完整该词含义再翻译,比如“发现结果” 。

Hyperphosphatasemia in an adult. Clinical, roentgenographic, and histomorphometric findings and comparison to classical Paget's disease.

作者信息

Einhorn T A, Vigorita V J, Teitcher J B

出版信息

Clin Orthop Relat Res. 1986 Mar(204):253-60.

PMID:3514034
Abstract

A 54-year-old man with short stature, diffuse skeletal abnormalities, and elevated alkaline phosphatase was evaluated by bone biopsy with undecalcified sections and morphometry analysis. Microscopically the bone changes were identical to those of classic Paget's disease. Histomorphometric analysis of bone demonstrated a high remodeling activity with increased mineralization rate similar to Paget's disease. However, the early age at onset and severity suggest that this man suffers from hyperphosphatasemia, a different and distinct condition.

摘要

一名54岁男性,身材矮小,全身骨骼异常,碱性磷酸酶升高,通过未脱钙切片骨活检和形态测量分析进行评估。显微镜下,骨骼变化与典型佩吉特病相同。骨组织形态计量学分析显示骨重塑活性高,矿化率增加,与佩吉特病相似。然而,发病年龄早和病情严重程度表明该男子患有高磷酸酶血症,这是一种不同的独特病症。

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