Wang Fei, Fei Min, Hu Wen-Zheng, Wang Xiao-Dan, Liu Shuai, Zeng Yan, Zhang Jin-Hong, Lv Yang, Niu Jian-Ping, Meng Xin-Ling, Cai Pan, Li Yang, Gang Bao-Zhi, You Yong, Lv Yan, Ji Yong
Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Department of Neurology, Yuncheng Central Hospital, Shanxi Medical University, Yuncheng, China.
Front Neurosci. 2022 Jan 24;15:821654. doi: 10.3389/fnins.2021.821654. eCollection 2021.
Constipation and dementia have similar epidemiological characteristics. Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two. Most of the studies on constipation in dementia patients have focused on the population with α-synucleinopathies [Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB)]. Few studies have reported the prevalence of constipation in all-cause dementia and mild cognitive impairment (MCI) populations.
To assess the prevalence of constipation in patients with all-cause dementia and MCI subtypes and to explore the association between constipation with dementia and MCI subtypes.
From May 2019 to December 2019, we conducted a population-based cross-sectional survey. A total of 11,743 participants aged 65 or older from nine cities in China were surveyed. Participants underwent a series of clinical examinations and neuropsychological measurements. Constipation, dementia, MCI and MCI subtype were diagnosed according to established criteria through standard diagnostic procedures.
The overall age- and sex-adjusted prevalence of constipation in individuals aged 65 years and older was 14.8% (95% CI, 14.6-15.0). The prevalence rates of constipation were19.2% (95% CI, 17.3-21.0), 19.1% (95% CI, 16.8-21.5), 14.4% (95% CI, 12.8-15.9), and 13.8% (95% CI, 13.0-14.6) in the dementia, non-amnestic (na)-MCI, amnestic (a)-MCI and normal cognition populations, respectively. Multivariate logistic regression analysis showed that higher prevalence of constipation was associated with dementia ( = 0.0.032, OR = 1.18, 95% CI: 1.02-1.38) and na-MCI ( = 0.003, OR = 1.30, 95% CI: 1.09-1.54).
The present study found a high prevalence of constipation in elderly individuals in China, and higher in patients with dementia and na-MCI.
便秘和痴呆具有相似的流行病学特征。肠道菌群的变化和脑-肠轴的特性在这两种疾病的发病机制中起作用，这表明两者之间可能存在密切联系。大多数关于痴呆患者便秘的研究都集中在α-突触核蛋白病患者群体（帕金森病痴呆症（PDD）、路易体痴呆症（DLB））。很少有研究报道全因性痴呆和轻度认知障碍（MCI）人群中便秘的患病率。
评估全因性痴呆和MCI亚型患者中便秘的患病率，并探讨便秘与痴呆和MCI亚型之间的关联。
2019年5月至2019年12月，我们进行了一项基于人群的横断面调查。对来自中国9个城市的11743名65岁及以上的参与者进行了调查。参与者接受了一系列临床检查和神经心理学测量。根据既定标准通过标准诊断程序诊断便秘、痴呆、MCI和MCI亚型。
65岁及以上人群中经年龄和性别调整后的便秘总体患病率为14.8%（95%CI，14.6-15.0）。痴呆、非遗忘型（na）-MCI、遗忘型（a）-MCI和正常认知人群中便秘的患病率分别为19.2%（95%CI，17.3-21.0）、19.1%（95%CI，16.8-21.5）、14.4%（95%CI，12.8-15.9）和13.8%（95%CI，13.0-14.6）。多因素逻辑回归分析表明，便秘患病率较高与痴呆（P=0.032，OR=1.18，95%CI：1.02-1.38）和na-MCI（P=0.003，OR=1.30，95%CI：1.09-1.54）相关。
本研究发现中国老年人便秘患病率较高，痴呆和na-MCI患者中患病率更高。
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