Department of Endocrinology, Dahua Hospital, Xuhui, Shanghai 200237, China.
J Healthc Eng. 2022 Jan 31;2022:3645336. doi: 10.1155/2022/3645336. eCollection 2022.
This study investigates the correlation between the gene polymorphism of rs8192675 (C/C) locus of SLC2A2 in patients with type 2 diabetes (T2DM) and the efficacy of metformin. For this purpose, we have selected 110 T2DM patients (T2DM group) and 110 healthy people (control group) who were treated in our hospital from January 2019 to January 2020 as the research subjects. PCR-restriction fragment length polymorphism (PCR-RFLP) method detects the distribution frequency of gene polymorphism. The patients in the T2DM group were treated with metformin and followed up for 90 days to analyze the relationship between the efficacy of metformin and the SLC2A2 gene polymorphism. The genotypes of SLC2A2 rs8192675 in the control group and in the T2DM group conformed to the Hardy-Weinberg equilibrium law. Compared with the control group, the CT type and the CC type at rs8192675 in the T2DM group were significantly higher ( < 0.05). For rs8192675, there was no significant difference in TT, CT, CC FPG, 2hPBG, and HbA1c levels before treatment ( > 0.05); after metformin treatment, the reduction in FPG, 2hPBG, and HbA1c in CC patients was lower than that of TT and CT patients ( < 0.05). SLC2A2 gene polymorphism site rs8192675 CC type T2DM patients are sensitive to metformin and have a better hypoglycemic effect.
本研究旨在探讨 SLC2A2 基因 rs8192675（C/C）位点多态性与 2 型糖尿病（T2DM）患者二甲双胍疗效的相关性。为此，我们选取了 2019 年 1 月至 2020 年 1 月在我院治疗的 110 例 T2DM 患者（T2DM 组）和 110 例健康人（对照组）作为研究对象。采用 PCR-限制性片段长度多态性（PCR-RFLP）法检测基因多态性的分布频率。T2DM 组患者采用二甲双胍治疗，并随访 90 天，分析二甲双胍疗效与 SLC2A2 基因多态性的关系。对照组和 T2DM 组 SLC2A2 rs8192675 基因型均符合 Hardy-Weinberg 平衡定律。与对照组相比，T2DM 组 rs8192675 的 CT 型和 CC 型明显更高（ < 0.05）。对于 rs8192675，TT、CT、CC 型治疗前 FPG、2hPBG、HbA1c 水平无显著差异（ > 0.05）；经二甲双胍治疗后，CC 型患者 FPG、2hPBG、HbA1c 下降幅度低于 TT 和 CT 型患者（ < 0.05）。SLC2A2 基因多态性位点 rs8192675 CC 型 T2DM 患者对二甲双胍敏感，降糖效果更好。
