Di Yu, Mo Fei, Li Ying
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
J Ophthalmol. 2022 Jan 31;2022:6994355. doi: 10.1155/2022/6994355. eCollection 2022.
The purpose of this study was to compare femtosecond laser-assisted in situ keratomileusis with prophylactic cross linking (FS-LASIK Xtra) and small-incision lenticule extraction with prophylactic cross linking (SMILE Xtra) in terms of their postoperative clinical outcomes.
In this retrospective study, 24 patients (48 eyes) with myopia and myopia astigmatism were recruited from 2017 to 2018. All patients underwent comprehensive ophthalmic examinations preoperatively and follow-up visits at one and three months. Four patients (eight eyes) in each group were followed up for 12 months. The following were assessed at each visit: uncorrected distance visual acuity (UDVA), manifest refractive spherical equivalent (MRSE), keratometry values, biomechanical properties, anterior and posterior curvature, and corneal pachymetry.
The FS-LASIK Xtra and SMILE Xtra groups both included 24 eyes of 12 patients. At 1, 3, and 12 months after surgery, a UDVA of 20/20 or better was achieved for 91.7%, 91.7%, and 87.5% of individuals, respectively, in the FS-LASIK group and 95.8%, 100%, and 100% in the SMILE group, respectively. For 75% of eyes in the FS-LASIK Xtra group and 100% of eyes in the SMILE Xtra group, the achieved MRSE was within ±1.00D of attempted correction. The LASIK Xtra group had a significantly higher mean MRSE than the SMILE Xtra group at 3 and 12 months after surgery (=0.006, 0.01), and the SMILE Xtra group had significantly higher 1 and 2 values than the FS-LASIK group at one month after surgery (=0.024, 0.023). Corneal thickness decreased significantly at one month postoperatively and started to increase over the next 12 months in both groups (=0.001). The biomechanical properties showed no significant intergroup differences at the 12-month follow-up.
FS-LASIK Xtra and SMILE Xtra are safe and effective in the correction of myopia and myopia astigmatism, and both procedures have the same effect on postoperative corneal morphology and biomechanics.
本研究旨在比较飞秒激光原位角膜磨镶术联合预防性交联（FS-LASIK Xtra）和小切口基质透镜切除术联合预防性交联（SMILE Xtra）的术后临床效果。
在这项回顾性研究中，2017年至2018年招募了24例（48眼）近视及近视散光患者。所有患者术前均接受全面眼科检查，并在术后1个月和3个月进行随访。每组4例（8眼）患者随访12个月。每次随访时评估以下指标：未矫正远视力（UDVA）、明显屈光球镜等效度（MRSE）、角膜曲率计值、生物力学特性、前后曲率及角膜厚度测量。
FS-LASIK Xtra组和SMILE Xtra组均包含12例患者的24眼。在术后1个月、3个月和12个月时，FS-LASIK组分别有91.7%、91.7%和87.5%的患者达到20/20或更好的UDVA，SMILE组分别为95.8%、100%和100%。FS-LASIK Xtra组75%的眼和SMILE Xtra组100%的眼，其获得的MRSE在预期矫正值的±1.00D范围内。LASIK Xtra组术后3个月和12个月时的平均MRSE显著高于SMILE Xtra组（=0.006，0.01），SMILE Xtra组术后1个月时的1和2值显著高于FS-LASIK组（=0.024，0.023）。两组术后1个月时角膜厚度均显著下降，在接下来的12个月开始增加（=0.001）。12个月随访时生物力学特性组间无显著差异。
FS-LASIK Xtra和SMILE Xtra在矫正近视及近视散光方面安全有效，且两种手术对术后角膜形态和生物力学的影响相同。
