Royal College of Surgeons in Ireland, Dublin, Ireland.
Digestive Healthcare of Georgia, Atlanta, Georgia, USA.
Cancer Rep (Hoboken). 2022 Sep;5(9):e1610. doi: 10.1002/cnr2.1610. Epub 2022 Feb 10.
Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine and nervous system. NETs, often found in the gastrointestinal tract, can be found anywhere in the body, and have metastatic potential. NETs occasionally present with metastatic disease without an identifiable primary tumor.
A 79-year-old female patient presented with an abdominal wall mass. Percutaneous biopsy was consistent with a NET. Preoperative endoscopy and PillCam were unremarkable. PET Dotatate demonstrated uptake in the abdominal wall as well as vague uptake in the pelvis. Intraoperatively, we identified a suspicious nodule on the sigmoid colon, which was consistent with a drop metastasis on final pathology.
In this case report we present a patient with a NET metastasis to the abdominal wall without a known primary site. This case highlights the limitations of endoscopy and imaging in the workup of metastatic NETs. Additionally, this is a novel case report of a metastatic NET to the abdominal wall without an identifiable primary site.
神经内分泌肿瘤(NETs)是起源于内分泌和神经系统细胞的肿瘤。NETs 通常在胃肠道中发现,但也可能在身体的任何部位出现,并具有转移的潜力。NETs 偶尔会出现转移性疾病而没有可识别的原发性肿瘤。
一名 79 岁女性患者出现腹壁肿块。经皮活检符合神经内分泌肿瘤。术前内镜和 PillCam 无异常。PET Dotatate 显示腹壁摄取以及骨盆模糊摄取。术中,我们在乙状结肠上发现一个可疑结节,最终病理结果显示为转移性腺瘤。
在本病例报告中,我们介绍了一例无明确原发病灶的腹壁神经内分泌肿瘤转移病例。该病例强调了内镜和影像学在转移性 NET 检查中的局限性。此外,这是一例无明确原发病灶的腹壁转移性 NET 的新病例报告。