Ookusa Y, Takata K, Nagashima M, Hirano H
Dermatologica. 1986;172(1):6-11.
Skin blisters at different stages were taken from 4 patients with bullous pemphigoid and studied mainly by scanning electron microscopy. The under-surface of the roof of the newly formed blisters was composed of columnar or cuboidal epidermal cells. Their intercellular space was dilated. Most of the cells were degenerated and shed off into the blister fluid. The under-surface of the roof of the fully developed blisters was composed of flattened epidermal cells which were polygonal in shape. These findings suggest that the basal cells are degenerated and shed off into the blister fluid, so that the prickle cells become flattened and directly face the blister fluid during blister formation.
从4例大疱性类天疱疮患者身上获取处于不同阶段的皮肤水疱，主要通过扫描电子显微镜进行研究。新形成水疱顶部的底面由柱状或立方形表皮细胞组成。它们的细胞间隙扩张。大多数细胞退化并脱落到疱液中。充分发展的水疱顶部的底面由扁平的多边形表皮细胞组成。这些发现表明，在水疱形成过程中，基底细胞退化并脱落到疱液中，从而使棘细胞变扁平并直接面对疱液。
