Man Xin-Yi, Chang Zao-Shang, Mo Yan-Xin, Liang Kai, Wang Le, Xiao Zhi-Yong
Department of Physiology, College of Basic Medicine, Shaoyang University.
Hunan Engineering Research Center of Development and Utilization of Traditional Chinese Medicine, Shaoyang University, Shaoyang.
Neuroreport. 2022 Mar 2;33(4):199-203. doi: 10.1097/WNR.0000000000001769.
Numerous studies suggest that the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type (AMPA) receptor appears to play a central role in mediating brain functions, such as learning and memory. Trafficking of this receptor is related to different long-term memory processes. This study explores the role of two AMPA receptor (AMPAR) modulators in object recognition memory (ORM) reconsolidation.
First, the effects of immediate administration of each drug after memory reactivation were investigated and compared. Then, this drug's efficient time window and its effects without memory reactivation were investigated.
Immediate CX546 administration after reactivation did not affect ORM reconsolidation. In contrast, administration of 10-mg/kg NBQX significantly impaired ORM reconsolidation within a 6-h time window. Importantly, the observed effects were not attributed to the exploratory behavior or locomotor activity of mice.
These findings provide new evidence that the AMPA receptor plays an important role in the reconsolidation phase of ORM.
大量研究表明，α-氨基-3-羟基-5-甲基-4-异恶唑丙酸型（AMPA）受体似乎在介导诸如学习和记忆等脑功能中发挥核心作用。该受体的转运与不同的长期记忆过程相关。本研究探讨两种AMPA受体（AMPAR）调节剂在物体识别记忆（ORM）重新巩固中的作用。
首先，研究并比较记忆重新激活后立即给予每种药物的效果。然后，研究该药物的有效时间窗及其在无记忆重新激活情况下的效果。
重新激活后立即给予CX546不影响ORM重新巩固。相比之下，给予10mg/kg NBQX在6小时时间窗内显著损害ORM重新巩固。重要的是，观察到的效果并非归因于小鼠的探索行为或运动活动。
这些发现提供了新的证据，表明AMPA受体在ORM重新巩固阶段发挥重要作用。
