Zadik Z, Levin P A, Hamilton B P, Kowarski A A
Hypertension. 1986 Apr;8(4):285-9. doi: 10.1161/01.hyp.8.4.285.
An outpatient diagnostic procedure measuring the 6-hour integrated plasma concentration of aldosterone and plasma renin activity was used to detect primary aldosteronism in 12 patients with low renin hypertension, including six with mild hypertension and normal urinary excretion and spot plasma levels of aldosterone. The ratio of integrated plasma concentration of aldosterone to plasma renin activity in the 12 patients (mean, 339; range, 116-700; p less than 0.0001) did not overlap with that measured in 105 normotensive controls (mean, 27.8; range, 5-97) or in 87 subjects with essential hypertension (mean, 29.2; range, 4-67). Eight patients had surgically proven adenomas (3 of which measured less than 5 mm) with normalization of blood pressure following adrenalectomy. The four remaining patients had bilateral hyperplasia. The 6-hour integrated plasma concentration of aldosterone to plasma renin activity ratio was found to be a useful new outpatient diagnostic tool for evaluation of primary hyperaldosteronism.
采用一项门诊诊断程序，测量醛固酮的6小时综合血浆浓度和血浆肾素活性，以检测12例低肾素性高血压患者的原发性醛固酮增多症，其中包括6例轻度高血压患者，其尿排泄正常，醛固酮的即时血浆水平正常。这12例患者的醛固酮综合血浆浓度与血浆肾素活性之比（均值为339；范围为116 - 700；p < 0.0001）与105例血压正常的对照者（均值为27.8；范围为5 - 97）或87例原发性高血压患者（均值为29.2；范围为4 - 67）所测结果无重叠。8例患者经手术证实患有腺瘤（其中3例直径小于5毫米），肾上腺切除术后血压恢复正常。其余4例患者为双侧增生。发现醛固酮的6小时综合血浆浓度与血浆肾素活性之比是评估原发性醛固酮增多症的一种有用的新型门诊诊断工具。
