Vucelić B, Hadzić N, Gragas J, Puretić Z
Int J Clin Pharmacol Ther Toxicol. 1986 Feb;24(2):93-6.
We report on the results of the clinical trial, where the effects of sucralfate on the serum phosphorus, calcium and alkaline phosphatase in 30 patients with chronic renal failure on intermittent hemodialysis were examined. After 14 days of treatment with sucralfate (1 gram four times daily), we found a significant reduction in serum phosphorus and alkaline phosphatase and an increase in serum calcium. On the basis of its proven hypophosphatemic and ulcer-healing effects, sucralfate can be recommended in treatment of hyperphosphatemia and secondary hyperparathyroidism in chronic renal failure. Serum phosphorus should be checked routinely in patients treated with sucralfate for the peptic ulcer disease.
我们报告了一项临床试验的结果，该试验检测了硫糖铝对30例接受间歇性血液透析的慢性肾衰竭患者血清磷、钙和碱性磷酸酶的影响。在用硫糖铝治疗14天（每日4次，每次1克）后，我们发现血清磷和碱性磷酸酶显著降低，血清钙升高。基于其已证实的降磷和促进溃疡愈合的作用，硫糖铝可推荐用于治疗慢性肾衰竭中的高磷血症和继发性甲状旁腺功能亢进。对于因消化性溃疡疾病接受硫糖铝治疗的患者，应常规检查血清磷。
