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经腹腔与腹膜后机器人辅助根治性上极肾部分切除术治疗完全位于上极的肾肿瘤患者的比较

Comparison of Transperitoneal and Retroperitoneal Robotic Partial Nephrectomy for Patients With Complete Upper Pole Renal Tumors.

作者信息

Gu Liangyou, Zhao Wenlei, Xu Junnan, Wang Baojun, Cheng Qiang, Shen Donglai, Xuan Yundong, Zhao Xupeng, Li Hongzhao, Ma Xin, Zhang Xu

机构信息

Department of Urology, the Third Medical Centre, Chinese PLA General Hospital, Beijing, China.

出版信息

Front Oncol. 2022 Jan 25;11:773345. doi: 10.3389/fonc.2021.773345. eCollection 2021.

Abstract

OBJECTIVES

We compared the outcomes of transperitoneal robotic partial nephrectomy (TRPN) and retroperitoneal robotic partial nephrectomy (RRPN) for complete upper pole renal masses (1 point for the "L" component of the RENAL scoring system).

MATERIAL AND METHODS

We retrospectively reviewed patients who underwent either TRPN or RRPN from 2013 to 2016. Baseline demographics and perioperative, functional, and oncological results were compared. Multivariable analysis was performed to identify factors related to pentafecta achievement (ischemia time ≤25 min, negative margin, perioperative complication free, glomerular filtration rate (eGFR) preservation >90%, and no chronic kidney disease upstaging).

RESULTS

No significant differences between TRPN RRPN were noted for operating time (110 114 min,  = 0.870), renal artery clamping time (19 18 min,  = 0.248), rate of positive margins (0.0% vs. 3.3%,  = 0.502), postoperative complication rates (25.0% 13.3%,  = 0.140). TRPN was associated with a more estimated blood loss (50 40 ml,  = 0.004). There were no significant differences in pathologic variables, rate of eGFR decline for postoperative 12-month (9.0% 7.1%,  = 0.449) functional follow-up. Multivariate analysis identified that only RENAL score (odd ratio: 0.641; 95% confidence interval: 0.455-0.904;  = 0.011) was independently associated with the pentafecta achievement.

CONCLUSIONS

For completely upper pole renal masses, both TRPN and RRPN have good and comparable results. Both surgical approaches remain viable options in the treatment of these cases.

摘要

目的

我们比较了经腹腔机器人辅助部分肾切除术(TRPN)和腹膜后机器人辅助部分肾切除术(RRPN)治疗完全位于上极的肾肿块(RENAL评分系统中“L”部分得1分)的疗效。

材料与方法

我们回顾性分析了2013年至2016年期间接受TRPN或RRPN手术的患者。比较了患者的基线人口统计学数据以及围手术期、功能和肿瘤学结果。进行多变量分析以确定与五项完美指标达成相关的因素(缺血时间≤25分钟、切缘阴性、无围手术期并发症、肾小球滤过率(eGFR)保留>90%以及无慢性肾脏病分期进展)。

结果

TRPN和RRPN在手术时间(110对114分钟,P = 0.870)、肾动脉阻断时间(19对18分钟,P = 0.248)、切缘阳性率(0.0%对3.3%,P = 0.502)、术后并发症发生率(25.0%对13.3%,P = 0.140)方面无显著差异。TRPN的估计失血量更多(50对40毫升,P = 0.004)。病理变量、术后12个月功能随访时eGFR下降率(9.0%对7.1%,P = 0.449)无显著差异。多变量分析确定只有RENAL评分(比值比:0.641;95%置信区间:0.455 - 0.904;P = 0.011)与五项完美指标达成独立相关。

结论

对于完全位于上极的肾肿块,TRPN和RRPN均有良好且相当的疗效。两种手术方式仍是治疗这些病例的可行选择。

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