Bui N B, Coindre J M, Chauvergne J, Maree D, Denepoux R, Mage P
J Chir (Paris). 1986 Jan;123(1):53-8.
Soft tissue sarcomas of adults represent an heterogeneous group of rare malignant tumors, for which clinical and histopathological prognostic factors are now well defined. The GTNM classification recommended by the UICC is effectively predictive for the metastatic potential of these diseases. Although chemotherapy still have limits in advanced sarcomas, the efficacy level reached allows to consider its use with a curative intend, in multidisciplinary therapeutic program. A critical analysis of the studies already published shows that adjuvant chemotherapy can reduce the distant metastases rate in patients presenting an operable primary tumor. Furthermore, the preliminary results of a study indicate that neoadjuvant (induction) chemotherapy may be of value for primarily inoperable patients. All these encouraging results remain to be confirmed by further studies with a long-term follow up of the patients.
成人软组织肉瘤是一组异质性罕见恶性肿瘤，目前临床和组织病理学预后因素已明确界定。国际抗癌联盟（UICC）推荐的GTNM分类对这些疾病的转移潜能具有有效的预测性。尽管化疗在晚期肉瘤中仍有局限性，但所达到的疗效水平使其可在多学科治疗方案中作为根治性手段加以考虑。对已发表研究的批判性分析表明，辅助化疗可降低原发性可手术肿瘤患者的远处转移率。此外，一项研究的初步结果表明，新辅助（诱导）化疗可能对原发性不可手术的患者有价值。所有这些令人鼓舞的结果仍有待通过对患者进行长期随访的进一步研究来证实。
