Chellingsworth M
J Clin Hosp Pharm. 1986 Feb;11(1):15-9. doi: 10.1111/j.1365-2710.1986.tb00824.x.
Since William Withering first described the use of digitalis, over 200 years ago (1), its popularity has waxed and waned. Digitalis preparations are widely prescribed for elderly patients. Surveys of hospital in-patients have shown a high prevalence of the use of digitalis preparations (2, 3), but also of digitalis toxicity; though not all studies have shown the latter to increase with age. A survey of people aged 70, living in Gothenberg, showed that 14% were taking digitalis preparations (4); other studies have shown similar figures. Now that powerful diuretics and vasodilators are available for the treatment of heart failure, and many antiarrhythmics are used for the control of atrial tachyarrhythmias, there is controversy about the value of cardiac glycosides in the treatment of elderly patients.
早在200多年前,威廉·威瑟林首次描述了洋地黄的用途(1),此后其受欢迎程度几经起伏。洋地黄制剂在老年患者中被广泛使用。对住院患者的调查显示,洋地黄制剂的使用率很高(2,3),洋地黄中毒的情况也很常见;不过并非所有研究都表明中毒发生率会随年龄增长。一项对居住在哥德堡的70岁人群的调查显示,14%的人正在服用洋地黄制剂(4);其他研究也得出了类似的数据。鉴于现在有强效利尿剂和血管扩张剂可用于治疗心力衰竭,并且许多抗心律失常药物可用于控制房性快速心律失常,因此关于强心苷在老年患者治疗中的价值存在争议。