FGF-FGFR 信号通路促进浸润性宫颈癌的发生发展。

FGF-FGFR signaling promotes the development of invasive cervical cancer.

机构信息

Department of Molecular Cell Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, Norway.

Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, Norway.

出版信息

FEBS J. 2022 Jun;289(12):3419-3421. doi: 10.1111/febs.16384. Epub 2022 Feb 11.

DOI:10.1111/febs.16384

PMID:35146913

Abstract

Cervical cancer is one of the most frequently diagnosed gynecological malignancies among women worldwide. The main cause of cervical cancer is the human papilloma virus (HPV). Mahmood et al. investigated in detail the role of the fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling axis in the development of the invasive form of the disease. The presented work clearly indicates the FGFR signaling as an additional but important factor for the development of a highly malignant tumor. Comment on https://doi.org/10.1111/febs.16331.

摘要

宫颈癌是全球女性中最常见的妇科恶性肿瘤之一。宫颈癌的主要病因是人乳头瘤病毒（HPV）。Mahmood 等人详细研究了成纤维细胞生长因子（FGF）-FGF 受体（FGFR）信号轴在疾病侵袭形式发展中的作用。本研究明确指出 FGFR 信号是高度恶性肿瘤发展的另一个重要因素。评论见 https://doi.org/10.1111/febs.16331。