Core Laboratory, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Department of Medical Innovation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Medicine (Baltimore). 2022 Feb 11;101(6):e28844. doi: 10.1097/MD.0000000000028844.
Heart failure is a major public health problem. Although there have been significant advances in the management of heart failure, the mortality and morbidity in heart failure patients remain high. Heart failure patients are susceptible to influenza-related complications including acute heart failure exacerbations and secondary infections such as pneumonia, both of which lead to significant morbidity and mortality. An earlier meta-analysis of observational cohort studies reported that influenza vaccination was associated with reduced risk of mortality in heart failure patients. Although there are no published randomized controlled trials (RCTs) on the effect of influenza vaccination on clinical outcomes in heart failure patients, there are several on-going RCTs examining the effect in these patients. We aim to conduct a meta-analysis of RCTs to assess the efficacy and safety of influenza vaccination in heart failure patients.
This meta-analysis will include RCTs examining the effect of influenza vaccination in heart failure patients. Information of studies will be collected from electronic databases. The primary outcome of interest will be cardiovascular death. The secondary outcomes of interest will be all-cause death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure, and hospitalization for any cause.
This meta-analysis will evaluate the efficacy and safety of influenza vaccination in heart failure patients, providing evidence to the use of influenza vaccine in these patients.
INPLASY202210115.
心力衰竭是一个主要的公共卫生问题。尽管心力衰竭的管理已经取得了重大进展，但心力衰竭患者的死亡率和发病率仍然很高。心力衰竭患者易患流感相关并发症，包括急性心力衰竭恶化和继发性感染，如肺炎，这两者都会导致发病率和死亡率显著增加。此前对观察性队列研究的荟萃分析报告称，流感疫苗接种与心力衰竭患者的死亡率降低相关。尽管目前尚无关于流感疫苗接种对心力衰竭患者临床结局影响的随机对照试验（RCT），但有几项正在进行的 RCT 正在研究这些患者中的效果。我们旨在进行一项 RCT 的荟萃分析，以评估流感疫苗接种在心力衰竭患者中的疗效和安全性。
本荟萃分析将包括评估流感疫苗接种对心力衰竭患者影响的 RCT。将从电子数据库中收集研究信息。主要观察终点为心血管死亡。次要观察终点为全因死亡、非致死性心肌梗死、非致死性卒中和心力衰竭住院以及任何原因的住院。
本荟萃分析将评估流感疫苗接种在心力衰竭患者中的疗效和安全性，为这些患者使用流感疫苗提供证据。
INPLASY202210115。
