Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE1 1UL, UK.
Development. 2022 Feb 1;149(3). doi: 10.1242/dev.200210. Epub 2022 Feb 11.
The mammalian main olfactory bulb is a crucial processing centre for the sense of smell. The olfactory bulb forms early during development and is functional from birth. However, the olfactory system continues to mature and change throughout life as a target of constitutive adult neurogenesis. Our Review synthesises current knowledge of prenatal, postnatal and adult olfactory bulb development, focusing on the maturation, morphology, functions and interactions of its diverse constituent glutamatergic and GABAergic cell types. We highlight not only the great advances in the understanding of olfactory bulb development made in recent years, but also the gaps in our present knowledge that most urgently require addressing.
哺乳动物的嗅球是嗅觉的关键处理中心。嗅球在发育早期形成，从出生起就具有功能。然而，随着成人神经发生的持续存在，嗅觉系统在整个生命过程中继续成熟和变化。我们的综述综合了目前关于嗅球发育的产前、产后和成人的知识，重点介绍了其不同谷氨酸能和 GABA 能细胞类型的成熟、形态、功能和相互作用。我们不仅强调了近年来在理解嗅球发育方面取得的巨大进展，还强调了我们目前知识中最迫切需要解决的空白。
