Staroukine M A, Giot J M, Verniory A E
J Hypertens. 1986 Feb;4(1):27-33. doi: 10.1097/00004872-198602000-00005.
The effect of intravenous (i.v.) captopril on mean arterial blood pressure (MABP) of anaesthetized normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats perfused i.v. with two doses of angiotensin II (ANG II; 2.9 and 5.8 pmol/kg per min) was studied to determine the role of the suppression of plasma ANG II in the hypotensive action of captopril. The reduction of MABP by captopril was attenuated in WKY and abolished in SHR by the highest dose of ANG II; it was unchanged in WKY and attenuated in SHR by the lowest dose of ANG II. The suppression of plasma ANG II thus explains a minor part of the acute reduction of MABP by captopril in WKY and a major part of this action in SHR. Plasma ANG II contributes to the maintenance of high blood pressure in SHR.
研究静脉注射卡托普利对静脉注射两种剂量血管紧张素II（ANG II；2.9和5.8 pmol/kg每分钟）的麻醉正常血压Wistar-Kyoto（WKY）大鼠和自发性高血压（SHR）大鼠平均动脉血压（MABP）的影响，以确定血浆ANG II抑制在卡托普利降压作用中的作用。在WKY大鼠中，卡托普利引起的MABP降低被最高剂量的ANG II减弱，在SHR大鼠中则被消除；在WKY大鼠中未改变，在SHR大鼠中被最低剂量的ANG II减弱。因此，血浆ANG II的抑制解释了卡托普利在WKY大鼠中引起的MABP急性降低的一小部分，以及在SHR大鼠中该作用的一大部分。血浆ANG II有助于SHR大鼠维持高血压。
