University of Ljubljana, Faculty of medicine Institute of physiology, Ljubljana, Slovenia.
Jožef Stefan Institute, Ljubljana, Slovenia.
Radiol Oncol. 2022 Feb 11;56(1):60-68. doi: 10.2478/raon-2022-0001.
The study was designed to evaluate the influence of hyperbaric oxygenation therapy (HBOT) on the parotid gland in patients following radiotherapy for head and neck tumours.
HBOT response was monitored by 3T magnetic resonance imaging (MRI) using mapping and subsequent measurement of mean and variability as well as by salivary tests (salivary flow, buffer capacity, and pH). Eighteen patients previously treated with irradiation doses between 50 and 80 Gy as well as 18 healthy gender and age matched controls were enrolled. MRI was performed prior to HBOT (40.2 ± 20 months after radiotherapy) and after 20 daily HBOT at 2.5 ATA (absolute atmosphere). Each HBOT consisted of breathing 100% oxygen for 90 minutes.
Significant differences in mean prior to HBOT were observed between the ipsilateral irradiated (121 ± 20 ms), contralateral parotids (107 ± 21) and control group (96 ± 12 ms). A positive correlation in patients between variability and irradiation dose was detected in contralateral parotids before HBOT (R = 0.489, p = 0.0287). In addition, negative correlations were observed between mean in the ipsilateral as well as the contralateral gland and salivary flow before and after HBOT. Negative correlations between mean , variability and pH of unstimulated saliva were also observed in the sides of parotid before and after HBOT.
The study confirmed that mapping had a potential for monitoring the differences between irradiated and normal parotid glands. It could also be useful in the assessment of the glandular tissue response to HBOT.
本研究旨在评估高压氧治疗（HBOT）对头颈部肿瘤放疗后患者腮腺的影响。
通过 3T 磁共振成像（MRI）使用 映射监测 HBOT 反应，随后测量均值和变异性以及唾液测试（唾液流量、缓冲能力和 pH 值）。共纳入 18 例先前接受 50 至 80Gy 放疗剂量的患者和 18 名性别和年龄匹配的健康对照组。MRI 在 HBOT 前（放疗后 40.2±20 个月）和 20 次每日 2.5ATA （绝对大气压）HBOT 后进行。每次 HBOT 包括呼吸 100%氧气 90 分钟。
在 HBOT 前，同侧照射（121±20ms）、对侧腮腺（107±21ms）和对照组（96±12ms）之间的均值 存在显著差异。在 HBOT 前，患者对侧腮腺中 变异性与照射剂量之间存在正相关（R=0.489，p=0.0287）。此外，在 HBOT 前后，同侧和对侧腺体的均值 与唾液流量之间存在负相关。在 HBOT 前后，腮腺两侧的均值 、变异性和未刺激唾液的 pH 值之间也存在负相关。
该研究证实了 映射在监测照射和正常腮腺之间的差异方面具有潜力。它还可用于评估腺体组织对 HBOT 的反应。
