Department of Gastroenterology, Xiangya Hospital, Central South University, China.
Department of Biliary and Pancreatic Surgery, Xiangya Hospital, Central South University, China.
J Coll Physicians Surg Pak. 2022 Mar;32(3):398-400. doi: 10.29271/jcpsp.2022.03.398.
Pancreatic acinar cell carcinoma (PACC) is a rare tumor of the exocrine pancreas. It accounts for only 1% of all pancreatic malignancies. A 39-year woman sought treatment for repeated abdominal pain and jaundice. The computed tomography (CT) and magnetic resonance imaging (MRI) suggested diffuse enlargement of the pancreas. 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT showed diffuse enlargement of the pancreas and increased glucose uptake. The endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy of the pancreas was performed, and the case was finally diagnosed as PACC. After the sixth course of chemotherapy with gemcitabine and albumin paclitaxel, a CT scan showed significant shrinkage of the pancreas. PACC very rarely presents with diffuse enlargement of the pancreas. This case illustrates a rare presentation of PACC with diffuse pancreatic enlargement, which was effectively treated with gemcitabine and albumin paclitaxel chemotherapy. Key Words: Pancreatic acinar cell carcinoma, Positron emission tomography/computed tomography, Chemotherapy.
胰腺腺泡细胞癌（PACC）是一种罕见的胰腺外分泌肿瘤。它仅占所有胰腺恶性肿瘤的 1%。一位 39 岁女性因反复腹痛和黄疸就诊。计算机断层扫描（CT）和磁共振成像（MRI）提示胰腺弥漫性肿大。18 F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）/CT 显示胰腺弥漫性肿大和葡萄糖摄取增加。对胰腺进行了内镜超声引导下细针抽吸（EUS-FNA）活检，最终诊断为 PACC。在接受吉西他滨和白蛋白紫杉醇化疗 6 个疗程后，CT 扫描显示胰腺明显缩小。PACC 很少表现为胰腺弥漫性肿大。本病例阐明了一种罕见的 PACC 表现为弥漫性胰腺肿大，吉西他滨和白蛋白紫杉醇化疗对此有效。关键词：胰腺腺泡细胞癌，正电子发射断层扫描/计算机断层扫描，化疗。
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