Discipline of Psychiatry and Mental Health, UNSW Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia; Karitane, P.O. Box 241, Villawood, NSW 2163, Australia.
Discipline of Psychiatry and Mental Health, UNSW Medicine and Health, University of New South Wales, Sydney, NSW 2052, Australia.
Neurosci Biobehav Rev. 2022 Apr;135:104573. doi: 10.1016/j.neubiorev.2022.104573. Epub 2022 Feb 9.
This study systematically reviewed available evidence regarding associations between polymorphisms of the oxytocin receptor (OXTR) gene and socio-emotional and behavioral functioning in children and adolescents. The search yielded 69 articles, which were grouped into nine categories: depression, anxiety, and internalizing symptoms, alcohol abuse, borderline personality disorder, conduct disorder symptoms or diagnosis, autism spectrum disorder, attention deficit hyperactivity disorder, early childhood attachment and behavior, pro-social skills, and resilience. Direct and/or gene x environment interactions were identified in over half of the studies. ASD and conduct disorder (including callous unemotional traits) were the diagnoses that were most studied and for which there was the strongest evidence of direct links with OXTR polymorphisms. In most studies identifying gene x environment interactions, the candidate OXTR polymorphism was rs53576. Results suggest that OXTR polymorphisms are associated with social, emotional or behavioural functioning in children and adolescents. The mixed findings do, however, highlight the need for further research.
本研究系统地回顾了有关催产素受体（OXTR）基因多态性与儿童和青少年社会情感和行为功能之间关联的现有证据。检索到 69 篇文章，这些文章分为九类：抑郁症、焦虑症和内向症状、酒精滥用、边缘型人格障碍、品行障碍症状或诊断、自闭症谱系障碍、注意缺陷多动障碍、幼儿依恋和行为、亲社会技能和适应力。超过一半的研究发现了直接和/或基因 x 环境相互作用。自闭症谱系障碍和品行障碍（包括无情特质）是研究最多的诊断，也是与 OXTR 多态性直接关联的最强证据。在大多数确定基因 x 环境相互作用的研究中，候选 OXTR 多态性是 rs53576。研究结果表明，OXTR 多态性与儿童和青少年的社会、情感或行为功能有关。然而，这些混杂的发现确实强调了进一步研究的必要性。
