Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, Anhui, 230032, People's Republic of China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, People's Republic of China.
Environ Sci Pollut Res Int. 2022 Jun;29(30):45783-45792. doi: 10.1007/s11356-022-19092-3. Epub 2022 Feb 12.
Meteorological variables are regarded as risk factors for inflammatory diseases, but their associations with uveitis, one of the leading causes accounting for blindness worldwide with an estimated prevalence of 38-714 cases/100,000 person-years, have not been thoroughly investigated. The present study explored the short-term association between meteorological variables and hospital admissions for uveitis in Hefei City, China. Daily data on uveitis hospital admissions and meteorological variables including mean temperature (MT) (°C), diurnal temperature range (DTR) (°C), and relative humidity (RH) (%), from 2014 to 2020, were collected. A time-series study using generalized linear model combined with distributed lag non-linear model was applied. Totally, 1911 admissions for uveitis including 894 first admissions and 1017 readmissions were reported during the study period. The associations of high percentile of MT (75th, 24.5℃) and low percentile of DTR (25th, 5.4℃) with uveitis admissions were observed to be statistically significant from lag9 (RR = 1.041, 95%CI: 1.002-1.081) to lag11 (RR = 1.053, 95%CI: 1.003-1.104) and lag4 (RR = 1.053, 95%CI: 1.019-1.088) to lag5 (RR = 1.052, 95%CI: 1.020-1.085), respectively. Moreover, a significant association between low percentile of RH (1th, 44%) and uveitis admissions appeared at lag0-8 (RR = 1.869, 95%CI: 1.017-3.434) and lasted until lag0-13 (RR = 2.539, 95%CI: 1.102-5.850) in the cumulative lag structure. Subgroup analyses indicated that males and the young seemed to be more sensitive to high MT exposure, while females appeared to be more vulnerable to low DTR exposure. Interestingly, both the young and the elderly are susceptible to low DTR and low RH exposure. Furthermore, high MT and low DTR exposure were associated with increased risk of first admission for uveitis. In summary, exposure to high-value of MT and low-value of DTR and RH may increase the hospital admissions for uveitis, especially for the status of first admission.
气象变量被认为是炎症性疾病的风险因素，但它们与葡萄膜炎的关系——葡萄膜炎是导致全球失明的主要原因之一，估计患病率为 38-714 例/10 万人年——尚未得到彻底研究。本研究探讨了气象变量与中国合肥市葡萄膜炎住院之间的短期关联。从 2014 年到 2020 年，每天收集葡萄膜炎住院和气象变量（包括平均温度（MT）（℃）、日温差（DTR）（℃）和相对湿度（RH）（%）的数据。采用广义线性模型与分布式滞后非线性模型相结合的时间序列研究。在研究期间，共报告了 1911 例葡萄膜炎住院病例，其中包括 894 例首次住院和 1017 例再住院。观察到高百分位数 MT（第 75 百分位，24.5℃）和低百分位数 DTR（第 25 百分位，5.4℃）与葡萄膜炎住院之间存在统计学显著关联，从滞后 9（RR=1.041，95%CI：1.002-1.081）到滞后 11（RR=1.053，95%CI：1.003-1.104）和滞后 4（RR=1.053，95%CI：1.019-1.088）到滞后 5（RR=1.052，95%CI：1.020-1.085）。此外，在累积滞后结构中，低百分位数 RH（第 1 百分位，44%）与葡萄膜炎住院之间的显著关联出现在滞后 0-8（RR=1.869，95%CI：1.017-3.434）和滞后 0-13（RR=2.539，95%CI：1.102-5.850）。亚组分析表明，男性和年轻人似乎对高 MT 暴露更敏感，而女性似乎对低 DTR 暴露更敏感。有趣的是，年轻人和老年人都容易受到低 DTR 和低 RH 暴露的影响。此外，高 MT 和低 DTR 暴露与葡萄膜炎首次住院的风险增加有关。总之，高 MT 值和低 DTR 值和 RH 值的暴露可能会增加葡萄膜炎的住院人数，特别是首次住院的人数。
