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无支架主动脉瓣置换与支架主动脉瓣置换治疗主动脉瓣狭窄。

Stentless Versus Stented Aortic Valve Replacement for Aortic Stenosis.

机构信息

Department of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.

Department of Cardiac Surgery, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.

出版信息

Ann Thorac Surg. 2022 Sep;114(3):728-734. doi: 10.1016/j.athoracsur.2022.01.029. Epub 2022 Feb 10.

Abstract

BACKGROUND

The differences in long-term outcomes of aortic valve replacement for aortic stenosis between stentless and stented bioprostheses are controversial.

METHODS

Between 2007 and 2018, 1173 patients underwent aortic valve replacement for aortic stenosis, including 559 treated with a stentless valve and 614 with a stented valve. A propensity score matched cohort with 348 pairs was generated by matching for age, sex, body surface area, bicuspid aortic valve, chronic lung disease, previous cardiac surgery, coronary artery disease, renal failure on dialysis, valve size, concomitant procedures, and surgeon. The primary endpoints of the study were long-term survival and incidence of reoperation.

RESULTS

Immediate postoperative outcomes were similar between the stentless and stented groups with an overall operative mortality of 2.9% (P = .19). Kaplan-Meier estimation for long-term survival was comparable between the stentless and stented valves in both the whole cohort and the propensity score matched cohort (10-year survival 59% vs 55%, P = .20). The hazard ratio of stentless vs stented valve for risk of long-term mortality was 1.12 (P = .33). The 10-year cumulative incidence of reoperation due to valve degeneration was 5.5% in the stentless group and 4.7% in the stented group (P = .25). The transvalvular pressure gradient at 5-year follow-up was significantly lower in the stentless group (7 vs 11 mm Hg, P < .001).

CONCLUSIONS

Both stented and stentless valves could be used in aortic valve replacement for aortic stenosis. We recommend stented valves for aortic valve replacement in patients with aortic stenosis for their simplicity of implantation.

摘要

背景

关于无支架和有支架生物瓣在主动脉瓣狭窄患者行主动脉瓣置换术后的长期预后存在争议。

方法

2007 年至 2018 年间,共有 1173 例主动脉瓣狭窄患者接受主动脉瓣置换术,其中 559 例患者使用无支架瓣膜,614 例患者使用有支架瓣膜。通过匹配年龄、性别、体表面积、二叶式主动脉瓣、慢性肺部疾病、既往心脏手术、冠状动脉疾病、透析肾衰、瓣膜大小、同期手术和外科医生等因素,生成了一个包含 348 对患者的倾向评分匹配队列。研究的主要终点是长期生存和再次手术的发生率。

结果

无支架组和有支架组的术后即刻结果相似,总体手术死亡率为 2.9%(P=.19)。无支架和有支架瓣膜在整个队列和倾向评分匹配队列中的长期生存 Kaplan-Meier 估计相似(10 年生存率分别为 59%和 55%,P=.20)。无支架与有支架瓣膜的长期死亡率风险比为 1.12(P=.33)。无支架组因瓣膜退行性变而再手术的 10 年累积发生率为 5.5%,有支架组为 4.7%(P=.25)。无支架组在 5 年随访时跨瓣压差显著低于有支架组(7 毫米汞柱与 11 毫米汞柱,P<.001)。

结论

对于主动脉瓣狭窄患者,有支架和无支架瓣膜均可用于主动脉瓣置换术。我们建议对于主动脉瓣狭窄患者,使用有支架瓣膜进行主动脉瓣置换术,因其植入更为简便。

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