Alyusuf Ebtihal Y, Alharthi Sahar, Alguwaihes Abdullah M, Jammah Anwar A, Alfadda Assim A, Al-Sofiani Mohammed E
Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Diabetes Metab Syndr. 2022 Feb;16(2):102416. doi: 10.1016/j.dsx.2022.102416. Epub 2022 Jan 31.
To identify predictors of use and benefit from continuous glucose monitoring (CGM) in people with type 1 diabetes (T1D).
Predictors of CGM use and changes in glycemic indices and other clinical parameters after initiating intermittently-scanned CGMs were examined in 116 individuals with T1D living in Saudi Arabia. Participants were categorized based on frequency of CGM sensor scanning at month 6 into: Frequent users (≥10 scans/day) and infrequent users (<10 scans/day).
Frequent CGM users had an improvement in time in range (TIR) and time above range (TAR) at months 6 and 12; whereas infrequent users had comparable improvements but only at month 12. Individuals with baseline TIR <50% had a significant improvement in TIR and TAR; whereas those with baseline TIR ≥50% had a significant improvement only in time below range (TBR). Baseline TIR <50% and higher frequency of scans were predictive of improvement in TIR at month 6 (OR: 4.84, p <0.01, 1.05, p= 0.04; respectively); whereas baseline TBR was the only predictor of improvement in TBR (OR:1.24,p < 0.01). Being a woman, higher number of scans/day during the first 2 weeks of CGM use, and having a lower A1C at baseline predict being a frequent scanner at month 6 (OR: 2.81, p=0.04; 1.12, p <0.01; and 0.73, p <0.01; respectively).
Improvement in glycemic control with CGM use can be predicted by: number of scans per day and baseline TIR and TBR in people with T1D.
确定1型糖尿病（T1D）患者持续葡萄糖监测（CGM）的使用预测因素及获益情况。
对沙特阿拉伯的116例T1D患者进行研究，观察CGM使用的预测因素以及开始间歇性扫描CGM后血糖指数和其他临床参数的变化。根据第6个月时CGM传感器扫描频率，将参与者分为：频繁使用者（≥10次/天）和不频繁使用者（<10次/天）。
频繁使用CGM的患者在第6个月和第12个月时，血糖达标时间（TIR）和高于目标范围时间（TAR）有所改善；而不频繁使用者虽有类似改善，但仅在第12个月时出现。基线TIR<50%的个体，TIR和TAR有显著改善；而基线TIR≥50%的个体，仅在低于目标范围时间（TBR）上有显著改善。基线TIR<50%和更高的扫描频率可预测第6个月时TIR的改善（OR分别为：4.84，p<0.01；1.05，p=0.04）；而基线TBR是TBR改善的唯一预测因素（OR：1.24，p<0.01）。女性、CGM使用前2周内每天扫描次数较多以及基线糖化血红蛋白（A1C）较低，可预测第6个月时为频繁扫描者（OR分别为：2.81，p=0.04；1.12，p<0.01；0.73，p<0.01）。
T1D患者使用CGM后血糖控制的改善可通过以下因素预测：每天扫描次数、基线TIR和TBR。
