Kumps A, Mardens Y
Ther Drug Monit. 1986;8(1):95-7. doi: 10.1097/00007691-198603000-00015.
To study the possible cross-reactivity of trans-10, 11-dihydroxy-10, 11-dihydro-carbamazepine (DHCBZ), the diol metabolite of carbamazepine (CBZ), of oxcarbazepine (OCZ), and of its metabolites in the CBZ-enzyme multiplied immunoassay technique (EMIT), this technique was used to analyze sera spiked with CBZ, OCZ, DHCBZ, and 10-hydroxy-10, 11-dihydro-carbamazepine (HCBZ). OCZ and, to a lesser extent, HCBZ cross-reacted with the CBZ-EMIT reagents. However, from a clinical point of view, only HCBZ could significantly interfere in the quantitation of CBZ levels in the plasma of patients taking both CBZ and OCZ. There was no interference by DHCBZ.
为研究卡马西平（CBZ）、奥卡西平（OCZ）及其代谢产物的二醇代谢物反式-10,11-二羟基-10,11-二氢卡马西平（DHCBZ）在CBZ-酶放大免疫分析技术（EMIT）中可能存在的交叉反应性，该技术被用于分析添加了CBZ、OCZ、DHCBZ和10-羟基-10,11-二氢卡马西平（HCBZ）的血清。OCZ以及程度较轻的HCBZ与CBZ-EMIT试剂发生了交叉反应。然而，从临床角度来看，只有HCBZ会显著干扰同时服用CBZ和OCZ患者血浆中CBZ水平的定量。DHCBZ没有干扰作用。
