MCM3AP-AS1：一种通过多种途径参与癌症发生的长链非编码 RNA。
MCM3AP-AS1: A LncRNA Participating in the Tumorigenesis of Cancer Through Multiple Pathways.
机构信息
College of Medical Science, China Three Gorges University, Yichang 443002, China.
College of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
出版信息
Mini Rev Med Chem. 2022;22(16):2138-2145. doi: 10.2174/1389557522666220214100718.
BACKGROUND
More and more shreds of evidence show that the occurrence and development of tumors are closely related to the abnormal expression of LncRNA. A large number of experiments have found that overexpression or under-expression of MCM3AP-AS1 can affect the occurrence and development of cancer cells in varying degrees, such as proliferation, invasion, and translocation. Besides, MCM3AP-AS1 may become a promising target for many tumor biotherapies. This article reviews the pathophysiological functions and molecular mechanisms of MCM3AP-AS1 in various tumors.
METHODS
This paper systematically summarizes the published literatures in PubMed. The molecular mechanism of MCM3AP-AS1 in a variety of tumors is reviewed.
RESULTS
The abnormal expression of MCM3AP-AS1 in different tumors is closely related to tumor proliferation, invasion, and migration. MCM3AP-AS1 mediates or participates in related signaling pathways to regulate the expression of targeted miRNAs and proteins. MCM3AP-AS1 plays a vital role in tumor diagnosis and treatment.
CONCLUSION
LncRNA MCM3AP-AS1 is a feasible tumor marker and a potential therapeutic target for many kinds of tumors.
背景
越来越多的证据表明，肿瘤的发生发展与 LncRNA 的异常表达密切相关。大量实验发现，MCM3AP-AS1 的过表达或低表达可以在不同程度上影响癌细胞的发生和发展，如增殖、侵袭和转移。此外，MCM3AP-AS1 可能成为许多肿瘤生物治疗的有前途的靶点。本文综述了 MCM3AP-AS1 在各种肿瘤中的病理生理功能和分子机制。
方法
本文系统地总结了 PubMed 上发表的文献。综述了 MCM3AP-AS1 在多种肿瘤中的分子机制。
结果
不同肿瘤中 MCM3AP-AS1 的异常表达与肿瘤的增殖、侵袭和迁移密切相关。MCM3AP-AS1 通过相关信号通路调节靶向 miRNA 和蛋白的表达，介导或参与相关信号通路。MCM3AP-AS1 在肿瘤的诊断和治疗中起着至关重要的作用。
结论
LncRNA MCM3AP-AS1 是多种肿瘤中一种可行的肿瘤标志物和潜在的治疗靶点。
Zotero 插件