多次输血可能导致镰状细胞贫血成年患者的肝脏和内分泌功能异常。

Multiple Blood Transfusion may contribute to Abnormal Liver and Endocrine Functions in Adults with Sickle Cell Anaemia.

机构信息

Department of Haematology & Blood Transfusion, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.

Department of Haematology & Immunology, Obafemi Awolowo University, Ile, Ife, Osun State, Nigeria.

出版信息

West Afr J Med. 2022 Jan 31;39(1):39-44.

PMID:35157404

Abstract

BACKGROUND

The study evaluated the effect of multiple blood transfusions on the prevalence of iron load and its effects on organ functions in patients with sickle cell anaemia (SCA).

METHODOLOGY

Sixty-seven multiply transfused SCA subjects and 58 non-multiply transfused SCA controls were investigated. Serum ferritin, insulin, growth hormone (GH), thyroid stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) were measured by the ELISA method while plasma alanine transaminase (ALT) was measured spectrophotometrically.

RESULTS

The median serum ferritin level was 364.97 (142.5-579.3) ng/ml and that of ALT was 12.20 (7.4-16.7) IU/l in the subjects and were significantly higher compared with 115.31 (81.3-285.6) ng/ml and 7.74(5.9-9.9) IU/l obtained in the controls (p <0.001 in each case). TSH was significantly lower 1.45 (0.4-2.9) µIU/ml in subjects compared with 2.12 (0.7-3.6) µIU/ml obtained in the controls (p = 0.034). The mean values for T4 in the subjects was 10.19 ± 1.5 µg/dl and was significantly higher compared with that of the controls of 9.57 ± 1.5 µg/dl (p = 0.026). However, there were no significant differences in the mean values of T3, GH and Insulin between the cases and the controls. There was a strong correlation between serum ferritin level and the number of units of blood transfused in the subjects (r = 0.575, p < 0.001).

CONCLUSION

The study found high serum ferritin level in multiply transfused SCA patients and which also correlated with the number of blood units transfused.

摘要

背景

本研究评估了多次输血对镰状细胞贫血（SCA）患者铁负荷的流行率及其对器官功能的影响。

方法

调查了 67 名多次输血的 SCA 患者和 58 名非多次输血的 SCA 对照组。采用 ELISA 法测定血清铁蛋白、胰岛素、生长激素（GH）、促甲状腺激素（TSH）、三碘甲状腺原氨酸（T3）和甲状腺素（T4），采用分光光度法测定血浆丙氨酸转氨酶（ALT）。

结果

患者的中位血清铁蛋白水平为 364.97（142.5-579.3）ng/ml，ALT 水平为 12.20（7.4-16.7）IU/l，明显高于对照组的 115.31（81.3-285.6）ng/ml 和 7.74（5.9-9.9）IU/l（p<0.001）。与对照组的 2.12（0.7-3.6）µIU/ml 相比，患者的 TSH 水平明显更低，为 1.45（0.4-2.9）µIU/ml（p=0.034）。患者的 T4 平均值为 10.19±1.5µg/dl，明显高于对照组的 9.57±1.5µg/dl（p=0.026）。然而，病例组和对照组的 T3、GH 和胰岛素的平均值之间没有显著差异。在患者中，血清铁蛋白水平与输血单位数之间存在很强的相关性（r=0.575，p<0.001）。