Eliasen K, Mogensen T, Andersen J B
Acta Anaesthesiol Scand. 1986 Jan;30(1):97-100. doi: 10.1111/j.1399-6576.1986.tb02375.x.
Peripheral airway pressure (Pp) was measured during high frequency ventilation (HFV) (open system) (1-20 Hz) by retrograde catheters in eight excised dog lungs. Central airway pressure (Pc) and pleural pressure (Ppl) were measured simultaneously. We found a significant increase in peripheral end-expiratory pressure at frequencies 5 Hz and higher, when the minute ventilation was increased. Mean Pc and mean Pp remained unchanged during ventilation at different frequencies with constant minute ventilation, although tidal volume decreased. With increasing tidal volume Pc, Pp, and Ppl (mean) increased at all frequencies. The increase in end-expiratory pressure indicates an "auto-PEEP" effect, which may contribute to the better gas exchange described during HFV.
在高频通气（HFV）（开放系统）（1 - 20Hz）期间，通过逆行导管在8个离体犬肺中测量外周气道压力（Pp）。同时测量中央气道压力（Pc）和胸膜压力（Ppl）。我们发现，当分钟通气量增加时，在5Hz及更高频率下外周呼气末压力显著增加。在分钟通气量恒定的情况下，不同频率通气期间平均Pc和平均Pp保持不变，尽管潮气量减少。随着潮气量增加，在所有频率下Pc、Pp和Ppl（平均值）均增加。呼气末压力的增加表明存在“自动呼气末正压”效应，这可能有助于解释高频通气期间描述的更好的气体交换。
