Zhong Zhijun, Li Qi, Zou Xueliang, Ouyang Qian, Zeng Qinghong, Hu Yinyin, Wang Mengmeng, Luo Yaxing, Yao Dongyuan
Neurological Institute of Jiangxi Province and Department of Neurology, Jiangxi Provincial People's Hospital, Nanchang Medical College and Nanchang University, Jiangxi, China.
Department of Neurology, The Third Affiliated Hospital, Nanchang University, Jiangxi, China.
J Oral Rehabil. 2022 May;49(5):495-504. doi: 10.1111/joor.13314. Epub 2022 Feb 21.
Obstructive sleep apnea (OSA) is associated with increases in QT interval corrected for heart rate (QTc interval) and QT variability index (QTVI) and sleep bruxism (SB) is prevalent in OSA patients.
To examine whether QTc interval and QT variability were changed during episodes of rhythmic masticatory muscle activities (RMMAs)/SB in SB patients with and without OSA.
The RR and QTc intervals, and QTVI during RMMAs with or without accompanied limb movements (RMMAs/LMs) in 10 normal controls and 10 SB patients without OSA and during apneic and recovery periods of OSA in 10 SB patients with OSA were analysed.
In the SB patients without OSA and controls, QTc intervals and QTVI were significantly increased during RMMAs/LMs compared with those during the 10 s periods (from 10 to 20 s) before the onset and after the offset of RMMAs/LMs, and significantly increased during RMMAs/LMs with awakenings compared with those with microarousals and no arousals. In addition, QTc interval and QTVI were positively correlated with the duration of RMMAs/LMs. Moreover, in the SB patients with OSA, QTc interval and QTVI during the recovery period of OSA events were significantly longer and higher than those during the apneic period regardless of accompanied RMMAs/LMs, and QTc interval and QTVI during the apneic and recovery periods accompanied with RMMAs/LMs were significantly longer and higher than those without accompanied RMMAs/LMs.
OSA and RMMAs/LMs events were associated with longer QTc intervals and higher QTVI, and RMMAs/LMs might contribute to these changes associated with OSA events accompanied with RMMAs/LMs.
阻塞性睡眠呼吸暂停（OSA）与心率校正后的QT间期（QTc间期）增加以及QT变异性指数（QTVI）有关，并且睡眠磨牙症（SB）在OSA患者中很普遍。
研究有或无OSA的SB患者在节律性咀嚼肌活动（RMMA）/SB发作期间QTc间期和QT变异性是否发生变化。
分析了10名正常对照者、10名无OSA的SB患者在伴有或不伴有肢体运动的RMMA（RMMA/LM）期间的RR和QTc间期以及QTVI，以及10名有OSA的SB患者在OSA的呼吸暂停期和恢复期的RR和QTc间期以及QTVI。
在无OSA的SB患者和对照组中，与RMMA/LM发作前10秒（从10秒到20秒）和发作后10秒相比，RMMA/LM期间QTc间期和QTVI显著增加，与伴有微觉醒和无觉醒的RMMA/LM相比，伴有觉醒的RMMA/LM期间QTc间期和QTVI显著增加。此外，QTc间期和QTVI与RMMA/LM的持续时间呈正相关。此外，在有OSA的SB患者中，无论是否伴有RMMA/LM，OSA事件恢复期的QTc间期和QTVI均显著长于和高于呼吸暂停期，伴有RMMA/LM的呼吸暂停期和恢复期的QTc间期和QTVI显著长于和高于不伴有RMMA/LM的情况。
OSA和RMMA/LM事件与更长的QTc间期和更高的QTVI相关，并且RMMA/LM可能导致这些与伴有RMMA/LM的OSA事件相关的变化。
