Department of Drug Addiction Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, Smętna 12, 31-343 Kraków, Poland.
Cells. 2022 Feb 4;11(3):540. doi: 10.3390/cells11030540.
Depression is one of the most common mental disorders in the general population, and multiple mechanisms are involved in the etiology of this disease, including myelination. According to the Developmental Origins of Health and Disease (DOHaD) hypothesis, maternal diet affects the lifetime of the individual during adulthood and may contribute to the development of neuropsychiatric disorders. Additionally, the intensive processes of myelination contribute to the development of the central nervous system in the perinatal period, while any alterations during this crucial process providing the physiological functioning of neurons may lead to neuropsychiatric disorders in the next generation. The present review summarizes the current knowledge on the role of the myelin-related changes in depression, as well as the crosstalk among maternal malnutrition, myelination, and depression in preclinical and clinical settings.
抑郁症是普通人群中最常见的精神障碍之一，这种疾病的病因涉及多种机制，包括髓鞘形成。根据健康与疾病的发育起源（DOHaD）假说，母体饮食会影响个体成年后的一生，并可能导致神经精神疾病的发生。此外，髓鞘形成的密集过程有助于围产期中枢神经系统的发育，而在此关键过程中的任何变化都可能导致下一代出现神经精神疾病。本文综述了目前关于抑郁症中与髓鞘相关变化的作用，以及在临床前和临床环境中母体营养不良、髓鞘形成和抑郁症之间相互作用的研究进展。
