活体肾供体对所提供信息及知情同意的了解：PRINCE研究

Living Kidney Donor Knowledge of Provided Information and Informed Consent: The PRINCE Study.

作者信息

Spoon Emerentia Q W, Kortram Kirsten, Ismail Sohal Y, Nieboer Daan, d'Ancona Frank C H, Christiaans Maarten H L, Dam Ruth E, Hofker Hendrik Sijbrand, Hoksbergen Arjan W J, van der Pant Karlijn Ami, Toorop Raechel J, van de Wetering Jacqueline, Ijzermans Jan N M, Dor Frank J M F

机构信息

Erasmus MC University Medical Centre, Department of Surgery, 3015 GD Rotterdam, The Netherlands.

Erasmus MC University Medical Centre, Department of Psychiatry, 3015 GD Rotterdam, The Netherlands.

出版信息

J Clin Med. 2022 Jan 28;11(3):698. doi: 10.3390/jcm11030698.

DOI:10.3390/jcm11030698

PMID:35160147

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8837079/

Abstract

BACKGROUND

Informed consent for living kidney donation is paramount, as donors are healthy individuals undergoing surgery for the benefit of others. The informed consent process for living kidney donors is heterogenous, and the question concerns how well they are actually informed. Knowledge assessments, before and after donor education, can form the basis for a standardized informed consent procedure for live kidney donation.

METHODS

In this prospective, a multicenter national cohort study conducted in all eight kidney transplant centers in The Netherlands, we assessed the current status of the informed consent practice for live donor nephrectomy. All of the potential living kidney donors in the participating centers were invited to participate. They completed a pop quiz during their first outpatient appointment (Cohort A). Living kidney donors completed the same pop quiz upon admission for donor nephrectomy (Cohort B).

RESULTS

In total, 656 pop quizzes were completed (417 in Cohort A, and 239 in Cohort B). The average donor knowledge score was 7.0/25.0 (±3.9, range 0-18) in Cohort A, and 10.5/25.0 (±2.8, range 0-17.5) in Cohort B. Cohort B scored significantly higher on overall knowledge, preparedness, and the individual item scores ( < 0.0001), except for the long-term complications ( = 0.91).

CONCLUSIONS

Donor knowledge generally improves during the live donor workup, but it is still quite disappointing. Long-term complications, especially, deserve more attention during living kidney donor education.

摘要

背景

对于活体肾捐赠而言，知情同意至关重要，因为捐赠者是为了他人利益而接受手术的健康个体。活体肾捐赠者的知情同意过程存在差异，问题在于他们实际获得的信息质量如何。在捐赠者教育前后进行知识评估，可为活体肾捐赠的标准化知情同意程序奠定基础。

方法

在荷兰所有八个肾脏移植中心开展的这项前瞻性多中心全国队列研究中，我们评估了活体供肾肾切除术知情同意实践的现状。邀请了参与中心的所有潜在活体肾捐赠者参与。他们在首次门诊预约时完成了一个突击测验（A队列）。活体肾捐赠者在入院接受供肾肾切除术时完成相同的突击测验（B队列）。

结果

总共完成了656份突击测验（A队列417份，B队列239份）。A队列捐赠者的平均知识得分是7.0/25.0（±3.9，范围0 - 18），B队列是10.5/25.0（±2.8，范围0 - 17.5）。B队列在总体知识、准备情况和各单项得分上显著更高（<0.0001），但长期并发症方面得分除外（=0.91）。